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Fréquence et titrage des hémolysines anti-A et anti-B chez les mères d’enfants ictériques à Yaoundé, Cameroun
INTRODUCTION: The alloimmunization of the ABO blood group system is involved in neonatal jaundice with a considerable overall prevalence. The role of ABO incompatibility is relatively little known. The purpose of this study was to investigate neonatal jaundice due to feto-maternal ABO incompatibilit...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The African Field Epidemiology Network
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170741/ https://www.ncbi.nlm.nih.gov/pubmed/32341734 http://dx.doi.org/10.11604/pamj.2020.35.13.14770 |
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author | Sock, David Sock Kamdem, Severin Donald Boula, Angeline Netongo, Palmer Masumbe |
author_facet | Sock, David Sock Kamdem, Severin Donald Boula, Angeline Netongo, Palmer Masumbe |
author_sort | Sock, David Sock |
collection | PubMed |
description | INTRODUCTION: The alloimmunization of the ABO blood group system is involved in neonatal jaundice with a considerable overall prevalence. The role of ABO incompatibility is relatively little known. The purpose of this study was to investigate neonatal jaundice due to feto-maternal ABO incompatibilities and to determine the link between the hemolysins value in the mother and the degree of jaundice observed in the infant. METHODS: We conducted a cross-sectional study from June to November 2015. The study population was exclusively composed of moms who were blood type O with children who were a different blood type hospitalized in the Department of Neonatology at the Reference Hospital in the city of Yaoundé. Statistical analyses were performed using the GraphPadPrism 6 software with a confidence interval of 95%. RESULTS: Hemolysins frequency was of 20.58% (7/34) and anti-A hemolysin was the most common type (85.7%; 6/7). The new-born who had blood type B had a greater concentration of bilirubin levels compared to those of the AB group (p = 0.01). Multiparity was not associated with the presence of hemolysin (p = 0.8) as well as blood type of the infant was not associated with the occurrence of the hemolysins in the mother (p = 0.5). CONCLUSION: Early neonatal jaundice or protracted neonatal jaundice are also caused by hemolysins anti-A and anti-B derived from the allo-ABO immunization. A study on a larger sample is recommended for better assessment. |
format | Online Article Text |
id | pubmed-7170741 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The African Field Epidemiology Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-71707412020-04-27 Fréquence et titrage des hémolysines anti-A et anti-B chez les mères d’enfants ictériques à Yaoundé, Cameroun Sock, David Sock Kamdem, Severin Donald Boula, Angeline Netongo, Palmer Masumbe Pan Afr Med J Research INTRODUCTION: The alloimmunization of the ABO blood group system is involved in neonatal jaundice with a considerable overall prevalence. The role of ABO incompatibility is relatively little known. The purpose of this study was to investigate neonatal jaundice due to feto-maternal ABO incompatibilities and to determine the link between the hemolysins value in the mother and the degree of jaundice observed in the infant. METHODS: We conducted a cross-sectional study from June to November 2015. The study population was exclusively composed of moms who were blood type O with children who were a different blood type hospitalized in the Department of Neonatology at the Reference Hospital in the city of Yaoundé. Statistical analyses were performed using the GraphPadPrism 6 software with a confidence interval of 95%. RESULTS: Hemolysins frequency was of 20.58% (7/34) and anti-A hemolysin was the most common type (85.7%; 6/7). The new-born who had blood type B had a greater concentration of bilirubin levels compared to those of the AB group (p = 0.01). Multiparity was not associated with the presence of hemolysin (p = 0.8) as well as blood type of the infant was not associated with the occurrence of the hemolysins in the mother (p = 0.5). CONCLUSION: Early neonatal jaundice or protracted neonatal jaundice are also caused by hemolysins anti-A and anti-B derived from the allo-ABO immunization. A study on a larger sample is recommended for better assessment. The African Field Epidemiology Network 2020-01-15 /pmc/articles/PMC7170741/ /pubmed/32341734 http://dx.doi.org/10.11604/pamj.2020.35.13.14770 Text en © David Sock Sock et al. http://creativecommons.org/licenses/by/2.0/ The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Sock, David Sock Kamdem, Severin Donald Boula, Angeline Netongo, Palmer Masumbe Fréquence et titrage des hémolysines anti-A et anti-B chez les mères d’enfants ictériques à Yaoundé, Cameroun |
title | Fréquence et titrage des hémolysines anti-A et anti-B chez les mères d’enfants ictériques à Yaoundé, Cameroun |
title_full | Fréquence et titrage des hémolysines anti-A et anti-B chez les mères d’enfants ictériques à Yaoundé, Cameroun |
title_fullStr | Fréquence et titrage des hémolysines anti-A et anti-B chez les mères d’enfants ictériques à Yaoundé, Cameroun |
title_full_unstemmed | Fréquence et titrage des hémolysines anti-A et anti-B chez les mères d’enfants ictériques à Yaoundé, Cameroun |
title_short | Fréquence et titrage des hémolysines anti-A et anti-B chez les mères d’enfants ictériques à Yaoundé, Cameroun |
title_sort | fréquence et titrage des hémolysines anti-a et anti-b chez les mères d’enfants ictériques à yaoundé, cameroun |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170741/ https://www.ncbi.nlm.nih.gov/pubmed/32341734 http://dx.doi.org/10.11604/pamj.2020.35.13.14770 |
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