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Tumor Development and Angiogenesis in Adult Brain Tumor: Glioblastoma
Angiogenesis is the growth of new capillaries from the preexisting blood vessels. Glioblastoma (GBM) tumors are highly vascularized tumors, and glioma growth depends on the formation of new blood vessels. Angiogenesis is a complex process involving proliferation, migration, and differentiation of va...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer US
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170819/ https://www.ncbi.nlm.nih.gov/pubmed/32152825 http://dx.doi.org/10.1007/s12035-020-01892-8 |
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author | Ahir, Bhavesh K. Engelhard, Herbert H. Lakka, Sajani S. |
author_facet | Ahir, Bhavesh K. Engelhard, Herbert H. Lakka, Sajani S. |
author_sort | Ahir, Bhavesh K. |
collection | PubMed |
description | Angiogenesis is the growth of new capillaries from the preexisting blood vessels. Glioblastoma (GBM) tumors are highly vascularized tumors, and glioma growth depends on the formation of new blood vessels. Angiogenesis is a complex process involving proliferation, migration, and differentiation of vascular endothelial cells (ECs) under the stimulation of specific signals. It is controlled by the balance between its promoting and inhibiting factors. Various angiogenic factors and genes have been identified that stimulate glioma angiogenesis. Therefore, attention has been directed to anti-angiogenesis therapy in which glioma proliferation is inhibited by inhibiting the formation of new tumor vessels using angiogenesis inhibitory factors and drugs. Here, in this review, we highlight and summarize the various molecular mediators that regulate GBM angiogenesis with focus on recent clinical research on the potential of exploiting angiogenic pathways as a strategy in the treatment of GBM patients. |
format | Online Article Text |
id | pubmed-7170819 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-71708192020-04-27 Tumor Development and Angiogenesis in Adult Brain Tumor: Glioblastoma Ahir, Bhavesh K. Engelhard, Herbert H. Lakka, Sajani S. Mol Neurobiol Article Angiogenesis is the growth of new capillaries from the preexisting blood vessels. Glioblastoma (GBM) tumors are highly vascularized tumors, and glioma growth depends on the formation of new blood vessels. Angiogenesis is a complex process involving proliferation, migration, and differentiation of vascular endothelial cells (ECs) under the stimulation of specific signals. It is controlled by the balance between its promoting and inhibiting factors. Various angiogenic factors and genes have been identified that stimulate glioma angiogenesis. Therefore, attention has been directed to anti-angiogenesis therapy in which glioma proliferation is inhibited by inhibiting the formation of new tumor vessels using angiogenesis inhibitory factors and drugs. Here, in this review, we highlight and summarize the various molecular mediators that regulate GBM angiogenesis with focus on recent clinical research on the potential of exploiting angiogenic pathways as a strategy in the treatment of GBM patients. Springer US 2020-03-09 2020 /pmc/articles/PMC7170819/ /pubmed/32152825 http://dx.doi.org/10.1007/s12035-020-01892-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Ahir, Bhavesh K. Engelhard, Herbert H. Lakka, Sajani S. Tumor Development and Angiogenesis in Adult Brain Tumor: Glioblastoma |
title | Tumor Development and Angiogenesis in Adult Brain Tumor: Glioblastoma |
title_full | Tumor Development and Angiogenesis in Adult Brain Tumor: Glioblastoma |
title_fullStr | Tumor Development and Angiogenesis in Adult Brain Tumor: Glioblastoma |
title_full_unstemmed | Tumor Development and Angiogenesis in Adult Brain Tumor: Glioblastoma |
title_short | Tumor Development and Angiogenesis in Adult Brain Tumor: Glioblastoma |
title_sort | tumor development and angiogenesis in adult brain tumor: glioblastoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170819/ https://www.ncbi.nlm.nih.gov/pubmed/32152825 http://dx.doi.org/10.1007/s12035-020-01892-8 |
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