Perturbing proteomes at single residue resolution using base editing

Base editors derived from CRISPR-Cas9 systems and DNA editing enzymes offer an unprecedented opportunity for the precise modification of genes, but have yet to be used at a genome-scale throughput. Here, we test the ability of the Target-AID base editor to systematically modify genes genome-wide by...

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Detalles Bibliográficos
Autores principales: Després, Philippe C., Dubé, Alexandre K., Seki, Motoaki, Yachie, Nozomu, Landry, Christian R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170841/
https://www.ncbi.nlm.nih.gov/pubmed/32313011
http://dx.doi.org/10.1038/s41467-020-15796-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170841/
https://www.ncbi.nlm.nih.gov/pubmed/32313011
http://dx.doi.org/10.1038/s41467-020-15796-7

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