High throughput pMHC-I tetramer library production using chaperone-mediated peptide exchange

Peptide exchange technologies are essential for the generation of pMHC-multimer libraries used to probe diverse, polyclonal TCR repertoires in various settings. Here, using the molecular chaperone TAPBPR, we develop a robust method for the capture of stable, empty MHC-I molecules comprising murine H...

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Detalles Bibliográficos
Autores principales: Overall, Sarah A., Toor, Jugmohit S., Hao, Stephanie, Yarmarkovich, Mark, Sara M. O’Rourke, Morozov, Giora I., Nguyen, Son, Japp, Alberto Sada, Gonzalez, Nicolas, Moschidi, Danai, Betts, Michael R., Maris, John M., Smibert, Peter, Sgourakis, Nikolaos G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170893/
https://www.ncbi.nlm.nih.gov/pubmed/32312993
http://dx.doi.org/10.1038/s41467-020-15710-1

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