Voltage-Dependent Protonation of the Calcium Pocket Enable Activation of the Calcium-Activated Chloride Channel Anoctamin-1 (TMEM16A)

Anoctamin-1 (ANO1 or TMEM16A) is a homo-dimeric Ca(2+)-activated Cl(−) channel responsible for essential physiological processes. Each monomer harbours a pore and a Ca(2+)-binding pocket; the voltage-dependent binding of two intracellular Ca(2+) ions to the pocket gates the pore. However, in the abs...

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Detalles Bibliográficos
Autores principales: Segura-Covarrubias, Guadalupe, Aréchiga-Figueroa, Iván A., De Jesús-Pérez, José J., Sánchez-Solano, Alfredo, Pérez-Cornejo, Patricia, Arreola, Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170896/
https://www.ncbi.nlm.nih.gov/pubmed/32313203
http://dx.doi.org/10.1038/s41598-020-62860-9

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