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Determining organ weight toxicity with Bayesian causal models: Improving on the analysis of relative organ weights

Regulatory authorities require animal toxicity tests for new chemical entities. Organ weight changes are accepted as a sensitive indicator of chemically induced organ damage, but can be difficult to interpret because changes in organ weight might reflect chemically-induced changes in overall body we...

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Detalles Bibliográficos
Autores principales: Lazic, Stanley E., Semenova, Elizaveta, Williams, Dominic P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170916/
https://www.ncbi.nlm.nih.gov/pubmed/32313041
http://dx.doi.org/10.1038/s41598-020-63465-y