Carnosol inhibits inflammasome activation by directly targeting HSP90 to treat inflammasome-mediated diseases

Aberrant activation of inflammasomes, a group of protein complexes, is pathogenic in a variety of metabolic and inflammation-related diseases. Here, we report that carnosol inhibits NLRP3 inflammasome activation by directly targeting heat-shock protein 90 (HSP90), which is essential for NLRP3 inflam...

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Detalles Bibliográficos
Autores principales: Shi, Wei, Xu, Guang, Zhan, Xiaoyan, Gao, Yuan, Wang, Zhilei, Fu, Shubin, Qin, Nan, Hou, Xiaorong, Ai, Yongqiang, Wang, Chunyu, He, Tingting, Liu, Hongbin, Chen, Yuanyuan, Liu, Yan, Wang, Jiabo, Niu, Ming, Guo, Yuming, Xiao, Xiaohe, Bai, Zhaofang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170921/
https://www.ncbi.nlm.nih.gov/pubmed/32312957
http://dx.doi.org/10.1038/s41419-020-2460-x

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