TRIM21 and PHLDA3 negatively regulate the crosstalk between the PI3K/AKT pathway and PPP metabolism

PI3K/AKT signaling is known to regulate cancer metabolism, but whether metabolic feedback regulates the PI3K/AKT pathway is unclear. Here, we demonstrate the important reciprocal crosstalk between the PI3K/AKT signal and pentose phosphate pathway (PPP) branching metabolic pathways. PI3K/AKT activati...

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Detalles Bibliográficos
Autores principales: Cheng, Jie, Huang, Yan, Zhang, Xiaohui, Yu, Yue, Wu, Shumin, Jiao, Jing, Tran, Linh, Zhang, Wanru, Liu, Ran, Zhang, Liuzhen, Wang, Mei, Wang, Mengyao, Yan, Wenyu, Wu, Yilin, Chi, Fangtao, Jiang, Peng, Zhang, Xinxiang, Wu, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170963/
https://www.ncbi.nlm.nih.gov/pubmed/32312982
http://dx.doi.org/10.1038/s41467-020-15819-3

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