Controlling Nutritional Status (CONUT) score is a prognostic factor in patients with resected breast cancer

The present study aimed to determine the correlation between controlling nutritional status (CONUT) and prognosis in resected breast cancer patients. Totally, 861 breast cancer patients with surgical resection in West China Hospital of Sichuan University between 2007 and 2010 were included. The rela...

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Autores principales: Li, Wen, Li, Min, Wang, Ting, Ma, Guangzhi, Deng, Yunfu, Pu, Dan, Liu, Zhenkun, Wu, Qiang, Liu, Xuejuan, Zhou, Qinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171067/
https://www.ncbi.nlm.nih.gov/pubmed/32313183
http://dx.doi.org/10.1038/s41598-020-63610-7
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author Li, Wen
Li, Min
Wang, Ting
Ma, Guangzhi
Deng, Yunfu
Pu, Dan
Liu, Zhenkun
Wu, Qiang
Liu, Xuejuan
Zhou, Qinghua
author_facet Li, Wen
Li, Min
Wang, Ting
Ma, Guangzhi
Deng, Yunfu
Pu, Dan
Liu, Zhenkun
Wu, Qiang
Liu, Xuejuan
Zhou, Qinghua
author_sort Li, Wen
collection PubMed
description The present study aimed to determine the correlation between controlling nutritional status (CONUT) and prognosis in resected breast cancer patients. Totally, 861 breast cancer patients with surgical resection in West China Hospital of Sichuan University between 2007 and 2010 were included. The relationship between CONUT and various clinicopathological factors as well as prognosis was evaluated. The results showed that the optimal cutoff value for CONUT to predict the 5-year survival was 3 and CONUT had a higher area under the ROC curve (AUC) for 5-year disease free survival (DFS) and overall survival (OS) prediction compared with the neutrophil lymphocyte ratio (NLR) and prognostic nutritional index (PNI). High CONUT was significantly correlated with older age, lymph node involvement, advanced T-stage, and surgery type. In the multivariate analysis, CONUT-high patients had worse DFS and OS, when compared with CONUT-low patients. In conclusion, preoperative CONUT is a useful marker for predicting long term outcomes in breast cancer patients after curative resection.
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spelling pubmed-71710672020-04-23 Controlling Nutritional Status (CONUT) score is a prognostic factor in patients with resected breast cancer Li, Wen Li, Min Wang, Ting Ma, Guangzhi Deng, Yunfu Pu, Dan Liu, Zhenkun Wu, Qiang Liu, Xuejuan Zhou, Qinghua Sci Rep Article The present study aimed to determine the correlation between controlling nutritional status (CONUT) and prognosis in resected breast cancer patients. Totally, 861 breast cancer patients with surgical resection in West China Hospital of Sichuan University between 2007 and 2010 were included. The relationship between CONUT and various clinicopathological factors as well as prognosis was evaluated. The results showed that the optimal cutoff value for CONUT to predict the 5-year survival was 3 and CONUT had a higher area under the ROC curve (AUC) for 5-year disease free survival (DFS) and overall survival (OS) prediction compared with the neutrophil lymphocyte ratio (NLR) and prognostic nutritional index (PNI). High CONUT was significantly correlated with older age, lymph node involvement, advanced T-stage, and surgery type. In the multivariate analysis, CONUT-high patients had worse DFS and OS, when compared with CONUT-low patients. In conclusion, preoperative CONUT is a useful marker for predicting long term outcomes in breast cancer patients after curative resection. Nature Publishing Group UK 2020-04-20 /pmc/articles/PMC7171067/ /pubmed/32313183 http://dx.doi.org/10.1038/s41598-020-63610-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Li, Wen
Li, Min
Wang, Ting
Ma, Guangzhi
Deng, Yunfu
Pu, Dan
Liu, Zhenkun
Wu, Qiang
Liu, Xuejuan
Zhou, Qinghua
Controlling Nutritional Status (CONUT) score is a prognostic factor in patients with resected breast cancer
title Controlling Nutritional Status (CONUT) score is a prognostic factor in patients with resected breast cancer
title_full Controlling Nutritional Status (CONUT) score is a prognostic factor in patients with resected breast cancer
title_fullStr Controlling Nutritional Status (CONUT) score is a prognostic factor in patients with resected breast cancer
title_full_unstemmed Controlling Nutritional Status (CONUT) score is a prognostic factor in patients with resected breast cancer
title_short Controlling Nutritional Status (CONUT) score is a prognostic factor in patients with resected breast cancer
title_sort controlling nutritional status (conut) score is a prognostic factor in patients with resected breast cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171067/
https://www.ncbi.nlm.nih.gov/pubmed/32313183
http://dx.doi.org/10.1038/s41598-020-63610-7
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