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A double-hit of stress and low-grade inflammation on functional brain network mediates posttraumatic stress symptoms
Growing evidence indicates a reciprocal relationship between low-grade systemic inflammation and stress exposure towards increased vulnerability to neuropsychiatric disorders, including posttraumatic stress disorder (PTSD). However, the neural correlates of this reciprocity and their influence on th...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171097/ https://www.ncbi.nlm.nih.gov/pubmed/32313055 http://dx.doi.org/10.1038/s41467-020-15655-5 |
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author | Kim, Jungyoon Yoon, Sujung Lee, Suji Hong, Haejin Ha, Eunji Joo, Yoonji Lee, Eun Hee Lyoo, In Kyoon |
author_facet | Kim, Jungyoon Yoon, Sujung Lee, Suji Hong, Haejin Ha, Eunji Joo, Yoonji Lee, Eun Hee Lyoo, In Kyoon |
author_sort | Kim, Jungyoon |
collection | PubMed |
description | Growing evidence indicates a reciprocal relationship between low-grade systemic inflammation and stress exposure towards increased vulnerability to neuropsychiatric disorders, including posttraumatic stress disorder (PTSD). However, the neural correlates of this reciprocity and their influence on the subsequent development of PTSD are largely unknown. Here we investigated alterations in functional connectivity among brain networks related to low-grade inflammation and stress exposure using two large independent data sets. Functional couplings among the higher-order cognitive network system including the salience, default mode, and central executive networks were reduced in association with low-grade inflammation and stress exposure. This reduced functional coupling may also be related to subsequent posttraumatic stress symptom severity. The current findings propose functional couplings among the higher-order cognitive network system as neural correlates of low-grade inflammation and stress exposure, and suggest that low-grade inflammation, alongside with stress, may render individuals more vulnerable to PTSD. |
format | Online Article Text |
id | pubmed-7171097 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-71710972020-04-23 A double-hit of stress and low-grade inflammation on functional brain network mediates posttraumatic stress symptoms Kim, Jungyoon Yoon, Sujung Lee, Suji Hong, Haejin Ha, Eunji Joo, Yoonji Lee, Eun Hee Lyoo, In Kyoon Nat Commun Article Growing evidence indicates a reciprocal relationship between low-grade systemic inflammation and stress exposure towards increased vulnerability to neuropsychiatric disorders, including posttraumatic stress disorder (PTSD). However, the neural correlates of this reciprocity and their influence on the subsequent development of PTSD are largely unknown. Here we investigated alterations in functional connectivity among brain networks related to low-grade inflammation and stress exposure using two large independent data sets. Functional couplings among the higher-order cognitive network system including the salience, default mode, and central executive networks were reduced in association with low-grade inflammation and stress exposure. This reduced functional coupling may also be related to subsequent posttraumatic stress symptom severity. The current findings propose functional couplings among the higher-order cognitive network system as neural correlates of low-grade inflammation and stress exposure, and suggest that low-grade inflammation, alongside with stress, may render individuals more vulnerable to PTSD. Nature Publishing Group UK 2020-04-20 /pmc/articles/PMC7171097/ /pubmed/32313055 http://dx.doi.org/10.1038/s41467-020-15655-5 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Kim, Jungyoon Yoon, Sujung Lee, Suji Hong, Haejin Ha, Eunji Joo, Yoonji Lee, Eun Hee Lyoo, In Kyoon A double-hit of stress and low-grade inflammation on functional brain network mediates posttraumatic stress symptoms |
title | A double-hit of stress and low-grade inflammation on functional brain network mediates posttraumatic stress symptoms |
title_full | A double-hit of stress and low-grade inflammation on functional brain network mediates posttraumatic stress symptoms |
title_fullStr | A double-hit of stress and low-grade inflammation on functional brain network mediates posttraumatic stress symptoms |
title_full_unstemmed | A double-hit of stress and low-grade inflammation on functional brain network mediates posttraumatic stress symptoms |
title_short | A double-hit of stress and low-grade inflammation on functional brain network mediates posttraumatic stress symptoms |
title_sort | double-hit of stress and low-grade inflammation on functional brain network mediates posttraumatic stress symptoms |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171097/ https://www.ncbi.nlm.nih.gov/pubmed/32313055 http://dx.doi.org/10.1038/s41467-020-15655-5 |
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