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The paternal and maternal genetic history of Vietnamese populations

Vietnam exhibits great cultural and linguistic diversity, yet the genetic history of Vietnamese populations remains poorly understood. Previous studies focused mostly on the majority Kinh group, and thus the genetic diversity of the many other groups has not yet been investigated. Here we analyze co...

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Autores principales: Macholdt, Enrico, Arias, Leonardo, Duong, Nguyen Thuy, Ton, Nguyen Dang, Van Phong, Nguyen, Schröder, Roland, Pakendorf, Brigitte, Van Hai, Nong, Stoneking, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171127/
https://www.ncbi.nlm.nih.gov/pubmed/31827276
http://dx.doi.org/10.1038/s41431-019-0557-4
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author Macholdt, Enrico
Arias, Leonardo
Duong, Nguyen Thuy
Ton, Nguyen Dang
Van Phong, Nguyen
Schröder, Roland
Pakendorf, Brigitte
Van Hai, Nong
Stoneking, Mark
author_facet Macholdt, Enrico
Arias, Leonardo
Duong, Nguyen Thuy
Ton, Nguyen Dang
Van Phong, Nguyen
Schröder, Roland
Pakendorf, Brigitte
Van Hai, Nong
Stoneking, Mark
author_sort Macholdt, Enrico
collection PubMed
description Vietnam exhibits great cultural and linguistic diversity, yet the genetic history of Vietnamese populations remains poorly understood. Previous studies focused mostly on the majority Kinh group, and thus the genetic diversity of the many other groups has not yet been investigated. Here we analyze complete mtDNA genome sequences and ~2.3 Mb sequences of the male-specific portion of the Y chromosome from the Kinh and 16 minority populations, encompassing all five language families present in Vietnam. We find highly variable levels of diversity within and between groups that do not correlate with either geography or language family. In particular, the Mang and Sila have undergone recent, independent bottlenecks, while the majority group, Kinh, exhibits low levels of differentiation with other groups. The two Austronesian-speaking groups, Giarai and Ede, show a potential impact of matrilocality on their patterns of variation. Overall, we find that isolation, coupled with limited contact involving some groups, has been the major factor influencing the genetic structure of Vietnamese populations, and that there is substantial genetic diversity that is not represented by the Kinh.
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spelling pubmed-71711272020-04-27 The paternal and maternal genetic history of Vietnamese populations Macholdt, Enrico Arias, Leonardo Duong, Nguyen Thuy Ton, Nguyen Dang Van Phong, Nguyen Schröder, Roland Pakendorf, Brigitte Van Hai, Nong Stoneking, Mark Eur J Hum Genet Article Vietnam exhibits great cultural and linguistic diversity, yet the genetic history of Vietnamese populations remains poorly understood. Previous studies focused mostly on the majority Kinh group, and thus the genetic diversity of the many other groups has not yet been investigated. Here we analyze complete mtDNA genome sequences and ~2.3 Mb sequences of the male-specific portion of the Y chromosome from the Kinh and 16 minority populations, encompassing all five language families present in Vietnam. We find highly variable levels of diversity within and between groups that do not correlate with either geography or language family. In particular, the Mang and Sila have undergone recent, independent bottlenecks, while the majority group, Kinh, exhibits low levels of differentiation with other groups. The two Austronesian-speaking groups, Giarai and Ede, show a potential impact of matrilocality on their patterns of variation. Overall, we find that isolation, coupled with limited contact involving some groups, has been the major factor influencing the genetic structure of Vietnamese populations, and that there is substantial genetic diversity that is not represented by the Kinh. Springer International Publishing 2019-12-11 2020-05 /pmc/articles/PMC7171127/ /pubmed/31827276 http://dx.doi.org/10.1038/s41431-019-0557-4 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Macholdt, Enrico
Arias, Leonardo
Duong, Nguyen Thuy
Ton, Nguyen Dang
Van Phong, Nguyen
Schröder, Roland
Pakendorf, Brigitte
Van Hai, Nong
Stoneking, Mark
The paternal and maternal genetic history of Vietnamese populations
title The paternal and maternal genetic history of Vietnamese populations
title_full The paternal and maternal genetic history of Vietnamese populations
title_fullStr The paternal and maternal genetic history of Vietnamese populations
title_full_unstemmed The paternal and maternal genetic history of Vietnamese populations
title_short The paternal and maternal genetic history of Vietnamese populations
title_sort paternal and maternal genetic history of vietnamese populations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171127/
https://www.ncbi.nlm.nih.gov/pubmed/31827276
http://dx.doi.org/10.1038/s41431-019-0557-4
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