Cargando…

Optogenetic manipulation of a value-coding pathway from the primate caudate tail facilitates saccadic gaze shift

In the primate basal ganglia, the caudate tail (CDt) encodes the historical values (good or bad) of visual objects (i.e., stable values), and electrical stimulation of CDt evokes saccadic eye movements. However, it is still unknown how output from CDt conveys stable value signals to govern behavior....

Descripción completa

Detalles Bibliográficos
Autores principales: Amita, Hidetoshi, Kim, Hyoung F., Inoue, Ken-ichi, Takada, Masahiko, Hikosaka, Okihide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171130/
https://www.ncbi.nlm.nih.gov/pubmed/32312986
http://dx.doi.org/10.1038/s41467-020-15802-y
_version_ 1783524012528238592
author Amita, Hidetoshi
Kim, Hyoung F.
Inoue, Ken-ichi
Takada, Masahiko
Hikosaka, Okihide
author_facet Amita, Hidetoshi
Kim, Hyoung F.
Inoue, Ken-ichi
Takada, Masahiko
Hikosaka, Okihide
author_sort Amita, Hidetoshi
collection PubMed
description In the primate basal ganglia, the caudate tail (CDt) encodes the historical values (good or bad) of visual objects (i.e., stable values), and electrical stimulation of CDt evokes saccadic eye movements. However, it is still unknown how output from CDt conveys stable value signals to govern behavior. Here, we apply a pathway-selective optogenetic manipulation to elucidate how such value information modulates saccades. We express channelrhodopsin-2 in CDt delivered by viral vector injections. Selective optical activation of CDt-derived terminals in the substantia nigra pars reticulata (SNr) inhibits SNr neurons. Notably, these SNr neurons show inhibitory responses to good objects. Furthermore, the optical stimulation causes prolonged excitation of visual-saccadic neurons in the superior colliculus (SC), and induces contralateral saccades. These SC neurons respond more strongly to good than to bad objects in the contralateral hemifield. The present results demonstrate that CDt facilitates saccades toward good objects by serial inhibitory pathways through SNr.
format Online
Article
Text
id pubmed-7171130
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-71711302020-04-23 Optogenetic manipulation of a value-coding pathway from the primate caudate tail facilitates saccadic gaze shift Amita, Hidetoshi Kim, Hyoung F. Inoue, Ken-ichi Takada, Masahiko Hikosaka, Okihide Nat Commun Article In the primate basal ganglia, the caudate tail (CDt) encodes the historical values (good or bad) of visual objects (i.e., stable values), and electrical stimulation of CDt evokes saccadic eye movements. However, it is still unknown how output from CDt conveys stable value signals to govern behavior. Here, we apply a pathway-selective optogenetic manipulation to elucidate how such value information modulates saccades. We express channelrhodopsin-2 in CDt delivered by viral vector injections. Selective optical activation of CDt-derived terminals in the substantia nigra pars reticulata (SNr) inhibits SNr neurons. Notably, these SNr neurons show inhibitory responses to good objects. Furthermore, the optical stimulation causes prolonged excitation of visual-saccadic neurons in the superior colliculus (SC), and induces contralateral saccades. These SC neurons respond more strongly to good than to bad objects in the contralateral hemifield. The present results demonstrate that CDt facilitates saccades toward good objects by serial inhibitory pathways through SNr. Nature Publishing Group UK 2020-04-20 /pmc/articles/PMC7171130/ /pubmed/32312986 http://dx.doi.org/10.1038/s41467-020-15802-y Text en © This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Amita, Hidetoshi
Kim, Hyoung F.
Inoue, Ken-ichi
Takada, Masahiko
Hikosaka, Okihide
Optogenetic manipulation of a value-coding pathway from the primate caudate tail facilitates saccadic gaze shift
title Optogenetic manipulation of a value-coding pathway from the primate caudate tail facilitates saccadic gaze shift
title_full Optogenetic manipulation of a value-coding pathway from the primate caudate tail facilitates saccadic gaze shift
title_fullStr Optogenetic manipulation of a value-coding pathway from the primate caudate tail facilitates saccadic gaze shift
title_full_unstemmed Optogenetic manipulation of a value-coding pathway from the primate caudate tail facilitates saccadic gaze shift
title_short Optogenetic manipulation of a value-coding pathway from the primate caudate tail facilitates saccadic gaze shift
title_sort optogenetic manipulation of a value-coding pathway from the primate caudate tail facilitates saccadic gaze shift
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171130/
https://www.ncbi.nlm.nih.gov/pubmed/32312986
http://dx.doi.org/10.1038/s41467-020-15802-y
work_keys_str_mv AT amitahidetoshi optogeneticmanipulationofavaluecodingpathwayfromtheprimatecaudatetailfacilitatessaccadicgazeshift
AT kimhyoungf optogeneticmanipulationofavaluecodingpathwayfromtheprimatecaudatetailfacilitatessaccadicgazeshift
AT inouekenichi optogeneticmanipulationofavaluecodingpathwayfromtheprimatecaudatetailfacilitatessaccadicgazeshift
AT takadamasahiko optogeneticmanipulationofavaluecodingpathwayfromtheprimatecaudatetailfacilitatessaccadicgazeshift
AT hikosakaokihide optogeneticmanipulationofavaluecodingpathwayfromtheprimatecaudatetailfacilitatessaccadicgazeshift