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Optogenetic manipulation of a value-coding pathway from the primate caudate tail facilitates saccadic gaze shift
In the primate basal ganglia, the caudate tail (CDt) encodes the historical values (good or bad) of visual objects (i.e., stable values), and electrical stimulation of CDt evokes saccadic eye movements. However, it is still unknown how output from CDt conveys stable value signals to govern behavior....
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171130/ https://www.ncbi.nlm.nih.gov/pubmed/32312986 http://dx.doi.org/10.1038/s41467-020-15802-y |
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author | Amita, Hidetoshi Kim, Hyoung F. Inoue, Ken-ichi Takada, Masahiko Hikosaka, Okihide |
author_facet | Amita, Hidetoshi Kim, Hyoung F. Inoue, Ken-ichi Takada, Masahiko Hikosaka, Okihide |
author_sort | Amita, Hidetoshi |
collection | PubMed |
description | In the primate basal ganglia, the caudate tail (CDt) encodes the historical values (good or bad) of visual objects (i.e., stable values), and electrical stimulation of CDt evokes saccadic eye movements. However, it is still unknown how output from CDt conveys stable value signals to govern behavior. Here, we apply a pathway-selective optogenetic manipulation to elucidate how such value information modulates saccades. We express channelrhodopsin-2 in CDt delivered by viral vector injections. Selective optical activation of CDt-derived terminals in the substantia nigra pars reticulata (SNr) inhibits SNr neurons. Notably, these SNr neurons show inhibitory responses to good objects. Furthermore, the optical stimulation causes prolonged excitation of visual-saccadic neurons in the superior colliculus (SC), and induces contralateral saccades. These SC neurons respond more strongly to good than to bad objects in the contralateral hemifield. The present results demonstrate that CDt facilitates saccades toward good objects by serial inhibitory pathways through SNr. |
format | Online Article Text |
id | pubmed-7171130 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-71711302020-04-23 Optogenetic manipulation of a value-coding pathway from the primate caudate tail facilitates saccadic gaze shift Amita, Hidetoshi Kim, Hyoung F. Inoue, Ken-ichi Takada, Masahiko Hikosaka, Okihide Nat Commun Article In the primate basal ganglia, the caudate tail (CDt) encodes the historical values (good or bad) of visual objects (i.e., stable values), and electrical stimulation of CDt evokes saccadic eye movements. However, it is still unknown how output from CDt conveys stable value signals to govern behavior. Here, we apply a pathway-selective optogenetic manipulation to elucidate how such value information modulates saccades. We express channelrhodopsin-2 in CDt delivered by viral vector injections. Selective optical activation of CDt-derived terminals in the substantia nigra pars reticulata (SNr) inhibits SNr neurons. Notably, these SNr neurons show inhibitory responses to good objects. Furthermore, the optical stimulation causes prolonged excitation of visual-saccadic neurons in the superior colliculus (SC), and induces contralateral saccades. These SC neurons respond more strongly to good than to bad objects in the contralateral hemifield. The present results demonstrate that CDt facilitates saccades toward good objects by serial inhibitory pathways through SNr. Nature Publishing Group UK 2020-04-20 /pmc/articles/PMC7171130/ /pubmed/32312986 http://dx.doi.org/10.1038/s41467-020-15802-y Text en © This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Amita, Hidetoshi Kim, Hyoung F. Inoue, Ken-ichi Takada, Masahiko Hikosaka, Okihide Optogenetic manipulation of a value-coding pathway from the primate caudate tail facilitates saccadic gaze shift |
title | Optogenetic manipulation of a value-coding pathway from the primate caudate tail facilitates saccadic gaze shift |
title_full | Optogenetic manipulation of a value-coding pathway from the primate caudate tail facilitates saccadic gaze shift |
title_fullStr | Optogenetic manipulation of a value-coding pathway from the primate caudate tail facilitates saccadic gaze shift |
title_full_unstemmed | Optogenetic manipulation of a value-coding pathway from the primate caudate tail facilitates saccadic gaze shift |
title_short | Optogenetic manipulation of a value-coding pathway from the primate caudate tail facilitates saccadic gaze shift |
title_sort | optogenetic manipulation of a value-coding pathway from the primate caudate tail facilitates saccadic gaze shift |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171130/ https://www.ncbi.nlm.nih.gov/pubmed/32312986 http://dx.doi.org/10.1038/s41467-020-15802-y |
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