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Erlotinib sensitivity of MAPK1p.D321N mutation in head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) lacks predictive biomarkers for drug responses. By targeted sequencing, we identified two MAPK1 mutations in recurrent HNSCC, MAPK1p.D321N, and p.R135K. We previously reported an exceptional erlotinib responder with MAPK1p.E322K. Here, by in silico and d...
Autores principales: | Ngan, Hoi-Lam, Poon, Peony Hiu Yan, Su, Yu-Xiong, Chan, Jason Ying Kuen, Lo, Kwok-Wai, Yeung, Chun Kit, Liu, Yuchen, Wong, Eileen, Li, Hui, Lau, Chin Wang, Piao, Wenying, Lui, Vivian Wai Yan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171136/ https://www.ncbi.nlm.nih.gov/pubmed/32351709 http://dx.doi.org/10.1038/s41525-020-0124-5 |
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