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S-Phase Kinase-associated Protein-2 Rejuvenates Senescent Endothelial Progenitor Cells and Induces Angiogenesis in Vivo

Cell cycle slowdown or arrest is a prominent feature of cellular senescence. S-phase kinase-associated protein-2 (Skp2), an F-box subunit of SCF(Skp2) ubiquitin ligase, is a key regulator of G1/S transition. We investigated whether Skp2 plays a role in the regulation of endothelial progenitor cell (...

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Detalles Bibliográficos
Autores principales:	Wang, Hsueh-Hsiao, Lee, Yi-Nan, Su, Cheng-Huang, Shu, Kuo-Tung, Liu, Wen-Ting, Hsieh, Chin-Ling, Yeh, Hung-I, Wu, Yih-Jer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171137/ https://www.ncbi.nlm.nih.gov/pubmed/32313103 http://dx.doi.org/10.1038/s41598-020-63716-y

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