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Pharmacological and genetic targeting of 5-lipoxygenase interrupts c-Myc oncogenic signaling and kills enzalutamide-resistant prostate cancer cells via apoptosis
Much of the morbidity and mortality due to prostate cancer happen because of castration-resistant prostate cancer (CRPC) which invariably develops after anti-androgenic therapy. FDA-approved enzalutamide is commonly prescribed for CRPC which works by blocking androgen receptor function. However, eve...
Autores principales: | Monga, Jitender, Subramani, Dhatchayini, Bharathan, Ajay, Ghosh, Jagadananda |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171151/ https://www.ncbi.nlm.nih.gov/pubmed/32313135 http://dx.doi.org/10.1038/s41598-020-62845-8 |
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