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A risk scoring system for the decreased glomerular filtration rate in Chinese general population

OBJECTIVE: The aim of this study was to establish a risk scoring system for the decreased glomerular filtration rate (GFR) in Chinese general population. METHODS: Totally 781 participants who underwent a health checkup in The First Affiliated Hospital of Nanjing Medical University from January to Se...

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Autores principales: Gu, Yan, Chen, Min, Zhu, Bei, Pei, Xiaohua, Yong, Zhenzhu, Li, Xiaona, Zhang, Qun, Zhao, Weihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171293/
https://www.ncbi.nlm.nih.gov/pubmed/31867757
http://dx.doi.org/10.1002/jcla.23143
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author Gu, Yan
Chen, Min
Zhu, Bei
Pei, Xiaohua
Yong, Zhenzhu
Li, Xiaona
Zhang, Qun
Zhao, Weihong
author_facet Gu, Yan
Chen, Min
Zhu, Bei
Pei, Xiaohua
Yong, Zhenzhu
Li, Xiaona
Zhang, Qun
Zhao, Weihong
author_sort Gu, Yan
collection PubMed
description OBJECTIVE: The aim of this study was to establish a risk scoring system for the decreased glomerular filtration rate (GFR) in Chinese general population. METHODS: Totally 781 participants who underwent a health checkup in The First Affiliated Hospital of Nanjing Medical University from January to September 2017 were involved in the study. Significant variables chosen by multivariable logistic regression analysis were allocated the integral scores in proportion to its odds ratio (OR), and then the risk of decreased GFR was assessed based on the scores. RESULTS: The people with abnormal homocysteine (Hcy) level (OR: 1.534, 95% confidential interval [CI]: 1.075‐2.190, P = .018), males (OR: 2.054, 95%CI: 1.365‐3.092, P < .001), and those at the age of 46‐52 years (OR: 2.943, 95%CI: 1.546‐5.605, P = .001), 52‐59 years (OR: 3.664, 95%CI: 1.937‐6.931, P < .001) and ≥59 years (OR: 13.452, 95%CI: 7.339‐24.657, P < .001) were subjected to GFR reduction. These three variables were allocated the integral scores in proportion to its OR, and four risk categories were divided according to the scores. The prevalence of the decreased GFR in people with low (score 0‐4, n = 8), below the average (score 4‐6, n = 37), above the average (score 6‐13, n = 47), and high risks (score ≥ 13, n = 103) was 5.26%, 16.89%, 22.93% and 50.24%, respectively, and this prevalence raised with the increase of scores (P < .001). CONCLUSIONS: A risk scoring system is developed in this study, which may offer a specific risk stratification for GFR reduction in Chinese general population.
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spelling pubmed-71712932020-04-21 A risk scoring system for the decreased glomerular filtration rate in Chinese general population Gu, Yan Chen, Min Zhu, Bei Pei, Xiaohua Yong, Zhenzhu Li, Xiaona Zhang, Qun Zhao, Weihong J Clin Lab Anal Research Articles OBJECTIVE: The aim of this study was to establish a risk scoring system for the decreased glomerular filtration rate (GFR) in Chinese general population. METHODS: Totally 781 participants who underwent a health checkup in The First Affiliated Hospital of Nanjing Medical University from January to September 2017 were involved in the study. Significant variables chosen by multivariable logistic regression analysis were allocated the integral scores in proportion to its odds ratio (OR), and then the risk of decreased GFR was assessed based on the scores. RESULTS: The people with abnormal homocysteine (Hcy) level (OR: 1.534, 95% confidential interval [CI]: 1.075‐2.190, P = .018), males (OR: 2.054, 95%CI: 1.365‐3.092, P < .001), and those at the age of 46‐52 years (OR: 2.943, 95%CI: 1.546‐5.605, P = .001), 52‐59 years (OR: 3.664, 95%CI: 1.937‐6.931, P < .001) and ≥59 years (OR: 13.452, 95%CI: 7.339‐24.657, P < .001) were subjected to GFR reduction. These three variables were allocated the integral scores in proportion to its OR, and four risk categories were divided according to the scores. The prevalence of the decreased GFR in people with low (score 0‐4, n = 8), below the average (score 4‐6, n = 37), above the average (score 6‐13, n = 47), and high risks (score ≥ 13, n = 103) was 5.26%, 16.89%, 22.93% and 50.24%, respectively, and this prevalence raised with the increase of scores (P < .001). CONCLUSIONS: A risk scoring system is developed in this study, which may offer a specific risk stratification for GFR reduction in Chinese general population. John Wiley and Sons Inc. 2019-12-22 /pmc/articles/PMC7171293/ /pubmed/31867757 http://dx.doi.org/10.1002/jcla.23143 Text en © 2019 The Authors. Journal of Clinical Laboratory Analysis Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Gu, Yan
Chen, Min
Zhu, Bei
Pei, Xiaohua
Yong, Zhenzhu
Li, Xiaona
Zhang, Qun
Zhao, Weihong
A risk scoring system for the decreased glomerular filtration rate in Chinese general population
title A risk scoring system for the decreased glomerular filtration rate in Chinese general population
title_full A risk scoring system for the decreased glomerular filtration rate in Chinese general population
title_fullStr A risk scoring system for the decreased glomerular filtration rate in Chinese general population
title_full_unstemmed A risk scoring system for the decreased glomerular filtration rate in Chinese general population
title_short A risk scoring system for the decreased glomerular filtration rate in Chinese general population
title_sort risk scoring system for the decreased glomerular filtration rate in chinese general population
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171293/
https://www.ncbi.nlm.nih.gov/pubmed/31867757
http://dx.doi.org/10.1002/jcla.23143
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