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The variation degree of coagulation function is not responsible for extra risk of hemorrhage in gestational diabetes mellitus

BACKGROUND: Gestational diabetes mellitus (GDM) is characterized as glucose intolerance of any degree that begins or first diagnosed during pregnancy. It possesses a higher risk of haemorrhage, which may be caused by the coagulation dysfunction. However, there has been no study focus on how coagulat...

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Autores principales: Dong, Chang, Gu, Xiaoqiong, Chen, Fei, Long, Yanlan, Zhu, Dan, Yang, Xia, Qiu, Xiu, Gao, Guoquan, Qi, WeiWei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171326/
https://www.ncbi.nlm.nih.gov/pubmed/31774215
http://dx.doi.org/10.1002/jcla.23129
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author Dong, Chang
Gu, Xiaoqiong
Chen, Fei
Long, Yanlan
Zhu, Dan
Yang, Xia
Qiu, Xiu
Gao, Guoquan
Qi, WeiWei
author_facet Dong, Chang
Gu, Xiaoqiong
Chen, Fei
Long, Yanlan
Zhu, Dan
Yang, Xia
Qiu, Xiu
Gao, Guoquan
Qi, WeiWei
author_sort Dong, Chang
collection PubMed
description BACKGROUND: Gestational diabetes mellitus (GDM) is characterized as glucose intolerance of any degree that begins or first diagnosed during pregnancy. It possesses a higher risk of haemorrhage, which may be caused by the coagulation dysfunction. However, there has been no study focus on how coagulation state changes in the progress of GDM pregnancy. Our study is aimed to assess the association of coagulation function and haemorrhage in GDM. METHODS: A total of 662 subjects (273 from a population‐based study and 389 from a prospective cohort study) were selected to measure mean platelet volume (MPV), platelet distribution width (PDW), platelet (PLT), thrombocytocrit (PCT), prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), and fibrinogen (FIB). All pregnant individuals were divided into normal glucose tolerance (NGT) controls and GDM patients diagnosed between the 24th and 28th weeks of gestation. RESULTS: Compared with NGT controls, GDM females showed shortened PT, shortened APTT, and increased blood FIB levels, while the platelet parameters MPV, PDW, PLT, and PCT remained unchanged in mid‐pregnancy. By late pregnancy, the platelet parameters MPV, PDW, and PCT were increased in the GDM group compared with the NGT group, while PT and APTT were unchanged. CONCLUSIONS: The GDM group was hypercoagulable compared with the NGT group rather than hypocoagulable as predicted, but still within the normal range. Therefore, our findings demonstrate that the variation degree of coagulation function is not responsible for extra risk of hemorrhage in GDM, and prevention of hemorrhage should focus on other causes.
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spelling pubmed-71713262020-04-21 The variation degree of coagulation function is not responsible for extra risk of hemorrhage in gestational diabetes mellitus Dong, Chang Gu, Xiaoqiong Chen, Fei Long, Yanlan Zhu, Dan Yang, Xia Qiu, Xiu Gao, Guoquan Qi, WeiWei J Clin Lab Anal Research Articles BACKGROUND: Gestational diabetes mellitus (GDM) is characterized as glucose intolerance of any degree that begins or first diagnosed during pregnancy. It possesses a higher risk of haemorrhage, which may be caused by the coagulation dysfunction. However, there has been no study focus on how coagulation state changes in the progress of GDM pregnancy. Our study is aimed to assess the association of coagulation function and haemorrhage in GDM. METHODS: A total of 662 subjects (273 from a population‐based study and 389 from a prospective cohort study) were selected to measure mean platelet volume (MPV), platelet distribution width (PDW), platelet (PLT), thrombocytocrit (PCT), prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), and fibrinogen (FIB). All pregnant individuals were divided into normal glucose tolerance (NGT) controls and GDM patients diagnosed between the 24th and 28th weeks of gestation. RESULTS: Compared with NGT controls, GDM females showed shortened PT, shortened APTT, and increased blood FIB levels, while the platelet parameters MPV, PDW, PLT, and PCT remained unchanged in mid‐pregnancy. By late pregnancy, the platelet parameters MPV, PDW, and PCT were increased in the GDM group compared with the NGT group, while PT and APTT were unchanged. CONCLUSIONS: The GDM group was hypercoagulable compared with the NGT group rather than hypocoagulable as predicted, but still within the normal range. Therefore, our findings demonstrate that the variation degree of coagulation function is not responsible for extra risk of hemorrhage in GDM, and prevention of hemorrhage should focus on other causes. John Wiley and Sons Inc. 2019-11-27 /pmc/articles/PMC7171326/ /pubmed/31774215 http://dx.doi.org/10.1002/jcla.23129 Text en © 2019 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Dong, Chang
Gu, Xiaoqiong
Chen, Fei
Long, Yanlan
Zhu, Dan
Yang, Xia
Qiu, Xiu
Gao, Guoquan
Qi, WeiWei
The variation degree of coagulation function is not responsible for extra risk of hemorrhage in gestational diabetes mellitus
title The variation degree of coagulation function is not responsible for extra risk of hemorrhage in gestational diabetes mellitus
title_full The variation degree of coagulation function is not responsible for extra risk of hemorrhage in gestational diabetes mellitus
title_fullStr The variation degree of coagulation function is not responsible for extra risk of hemorrhage in gestational diabetes mellitus
title_full_unstemmed The variation degree of coagulation function is not responsible for extra risk of hemorrhage in gestational diabetes mellitus
title_short The variation degree of coagulation function is not responsible for extra risk of hemorrhage in gestational diabetes mellitus
title_sort variation degree of coagulation function is not responsible for extra risk of hemorrhage in gestational diabetes mellitus
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171326/
https://www.ncbi.nlm.nih.gov/pubmed/31774215
http://dx.doi.org/10.1002/jcla.23129
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