Cargando…

METTL3/YTHDF2 m(6)A axis promotes tumorigenesis by degrading SETD7 and KLF4 mRNAs in bladder cancer

N6‐Methyladenosine (m(6)A) modification, the most prevalent modification of eukaryotic messenger RNA (mRNA), is involved in the progression of various tumours. However, the specific role of m(6)A in bladder cancer (BCa) is still poorly understood. In this study, we demonstrated the tumour‐promoting...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xie, Haiyun, Li, Jiangfeng, Ying, Yufan, Yan, Huaqing, Jin, Ke, Ma, Xueyou, He, Liujia, Xu, Xin, Liu, Ben, Wang, Xiao, Zheng, Xiangyi, Xie, Liping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171394/ https://www.ncbi.nlm.nih.gov/pubmed/32126149 http://dx.doi.org/10.1111/jcmm.15063

Ejemplares similares

YTHDF2 mediates the mRNA degradation of the tumor suppressors to induce AKT phosphorylation in N6-methyladenosine-dependent way in prostate cancer
por: Li, Jiangfeng, et al.
Publicado: (2020)

CCND1, NOP14 and DNMT3B are involved in miR‐502‐5p–mediated inhibition of cell migration and proliferation in bladder cancer
por: Ying, Yufan, et al.
Publicado: (2020)

EGR2-mediated regulation of m(6)A reader IGF2BP proteins drive RCC tumorigenesis and metastasis via enhancing S1PR3 mRNA stabilization
por: Ying, Yufan, et al.
Publicado: (2021)

The dual role of N6‐methyladenosine modification of RNAs is involved in human cancers
por: He, Liujia, et al.
Publicado: (2018)

Secondhand smoking increases bladder cancer risk in nonsmoking population: a meta-analysis
por: Yan, Huaqing, et al.
Publicado: (2018)

CRISPR-ON-Mediated KLF4 overexpression inhibits the proliferation, migration and invasion of urothelial bladder cancer in vitro and in vivo
por: Xu, Xin, et al.
Publicado: (2017)

MicroRNA‐501‐3p inhibits the proliferation of kidney cancer cells by targeting WTAP
por: He, Liujia, et al.
Publicado: (2021)

circKDM4C enhances bladder cancer invasion and metastasis through miR-200bc-3p/ZEB1 axis
por: Ma, Xueyou, et al.
Publicado: (2021)

Pioglitazone use in patients with diabetes and risk of bladder cancer: a systematic review and meta-analysis
por: Yan, Huaqing, et al.
Publicado: (2018)

METTL14 promotes prostate tumorigenesis by inhibiting THBS1 via an m6A-YTHDF2-dependent mechanism
por: Wang, Yongjie, et al.
Publicado: (2022)

m(6)A and YTHDF proteins contribute to the localization of select neuronal mRNAs
por: Flamand, Mathieu N, et al.
Publicado: (2022)

YTHDF1 Promotes Bladder Cancer Cell Proliferation via the METTL3/YTHDF1–RPN2–PI3K/AKT/mTOR Axis
por: Zhu, Junlong, et al.
Publicado: (2023)

METTL3/YTHDF2 m6A axis promotes the malignant progression of bladder cancer by epigenetically suppressing RRAS
por: Chen, Jie-Xun, et al.
Publicado: (2023)

FTO promotes clear cell renal cell carcinoma progression via upregulation of PDK1 through an m(6)A dependent pathway
por: Shen, Haixiang, et al.
Publicado: (2022)

METTL3 Facilitates Oral Squamous Cell Carcinoma Tumorigenesis by Enhancing c-Myc Stability via YTHDF1-Mediated m(6)A Modification
por: Zhao, Wei, et al.
Publicado: (2020)

Downregulation of N(6)-methyladenosine binding YTHDF2 protein mediated by miR-493-3p suppresses prostate cancer by elevating N(6)-methyladenosine levels
por: Li, Jiangfeng, et al.
Publicado: (2017)

The Regulatory Role of RNA Metabolism Regulator TDP-43 in Human Cancer
por: Ma, Xueyou, et al.
Publicado: (2021)

METTL3 promotes prostatic hyperplasia by regulating PTEN expression in an m(6)A-YTHDF2-dependent manner
por: Li, Jiaren, et al.
Publicado: (2022)

METTL3 facilitates immunosurveillance by inhibiting YTHDF2-mediated NLRC5 mRNA degradation in endometrial cancer
por: Zhan, Lei, et al.
Publicado: (2023)

Curdione induces ferroptosis mediated by m6A methylation via METTL14 and YTHDF2 in colorectal cancer
por: Wang, Fang, et al.
Publicado: (2023)

Exploration of N6-Methyladenosine Profiles of mRNAs and the Function of METTL3 in Atherosclerosis
por: Zhou, Yaqing, et al.
Publicado: (2022)

Roles of N(6)‐methyladenosine (m(6)A) RNA modifications in urological cancers
por: Wang, Xiao, et al.
Publicado: (2020)

SUMOylation of YTHDF2 promotes mRNA degradation and cancer progression by increasing its binding affinity with m(6)A-modified mRNAs
por: Hou, Guofang, et al.
Publicado: (2021)

METTL3/YTHDF2 m6A axis accelerates colorectal carcinogenesis through epigenetically suppressing YPEL5
por: Zhou, Dan, et al.
Publicado: (2021)

METTL14 reverses liver fibrosis by inhibiting NOVA2 through an m(6)A-YTHDF2–dependent mechanism
por: Hou, Xiaoxue, et al.
Publicado: (2023)

DDX5/METTL3-METTL14/YTHDF2 Axis Regulates Replication of Influenza A Virus
por: Zhao, Lingcai, et al.
Publicado: (2022)

N(6)-methyladenosine METTL3 promotes cervical cancer tumorigenesis and Warburg effect through YTHDF1/HK2 modification
por: Wang, Qianqing, et al.
Publicado: (2020)

KLF4 transcription factor in tumorigenesis
por: He, Zhihong, et al.
Publicado: (2023)

SMAD3 and FTO are involved in miR-5581-3p-mediated inhibition of cell migration and proliferation in bladder cancer
por: Sun, Jiazhu, et al.
Publicado: (2022)

YTHDF1 mitigates acute kidney injury via safeguarding m(6)A-methylated mRNAs in stress granules of renal tubules
por: Yang, Wenwen, et al.
Publicado: (2023)

METTL3 promotes intrahepatic cholangiocarcinoma progression by regulating IFIT2 expression in an m(6)A-YTHDF2-dependent manner
por: Xu, Qiong-Cong, et al.
Publicado: (2022)

METTL3 enhances the effect of YTHDF1 on NEDD1 mRNA stability by m6A modification in diffuse large B‐cell lymphoma cells
por: Feng, Lili, et al.
Publicado: (2023)

The SUMOylated METTL8 Induces R-loop and Tumorigenesis via m3C
por: Zhang, Li-Hong, et al.
Publicado: (2020)

METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N(6)-methyladenosine-dependent YTHDF binding
por: Wang, Wei, et al.
Publicado: (2021)

MEF2C Expression Is Regulated by the Post-transcriptional Activation of the METTL3-m(6)A-YTHDF1 Axis in Myoblast Differentiation
por: Yang, Xinran, et al.
Publicado: (2022)

METTL3 promotes cell cycle progression via m(6)A/YTHDF1-dependent regulation of CDC25B translation
por: Li, Huifeng, et al.
Publicado: (2022)

Upregulation of ARNTL2 is associated with poor survival and immune infiltration in clear cell renal cell carcinoma
por: Wang, Song, et al.
Publicado: (2021)

Comprehensive Analysis of Ferroptosis Regulators With Regard to PD-L1 and Immune Infiltration in Clear Cell Renal Cell Carcinoma
por: Wang, Song, et al.
Publicado: (2021)

SETD2 regulates chromatin accessibility and transcription to suppress lung tumorigenesis
por: Xie, Yuchen, et al.
Publicado: (2023)

METTL1 drives tumor progression of bladder cancer via degrading ATF3 mRNA in an m(7)G-modified miR-760-dependent manner
por: Xie, Haiyun, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3b9pghemmsrthm872vjftoj8aa