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Cell proliferation and invasion is promoted by circSERPINA3 in nasopharyngeal carcinoma by regulating miR-944/MDM2 axis

Growing evidence has demonstrated that in tumor progression, circular RNAs (circRNAs) play important roles. However, the roles of circRNAs in nasopharyngeal carcinoma (NPC) have not been fully elucidated. In this study, it was demonstrated that that hsa_circ_0033074 (circSERPINA3) expression was fou...

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Detalles Bibliográficos
Autores principales: Liu, Rui, Zhou, Minghui, Zhang, Puwen, Zhao, Yulin, Zhang, Yujie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171482/
https://www.ncbi.nlm.nih.gov/pubmed/32328195
http://dx.doi.org/10.7150/jca.42799
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author Liu, Rui
Zhou, Minghui
Zhang, Puwen
Zhao, Yulin
Zhang, Yujie
author_facet Liu, Rui
Zhou, Minghui
Zhang, Puwen
Zhao, Yulin
Zhang, Yujie
author_sort Liu, Rui
collection PubMed
description Growing evidence has demonstrated that in tumor progression, circular RNAs (circRNAs) play important roles. However, the roles of circRNAs in nasopharyngeal carcinoma (NPC) have not been fully elucidated. In this study, it was demonstrated that that hsa_circ_0033074 (circSERPINA3) expression was found to be significantly upregulated in NPC tissues and cell lines. CircSERPINA3 inhibition significantly attenuated the invasion and proliferation abilities of NPC cells. The mechanism by which circSERPINA3 interacted with miR-944 was identified and MDM2 was demonstrated to function as a target gene of miR-944. Rescue experiments showed that miR-944 inhibitors or MDM2 overexpression reserved the effects of circSERPINA3 knockdown on NPC progression. Therefore, our study uncovered the circSERPINA3/miR-944/MDM2 axis in NPC, which may be a potential NPC therapeutic target.
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spelling pubmed-71714822020-04-23 Cell proliferation and invasion is promoted by circSERPINA3 in nasopharyngeal carcinoma by regulating miR-944/MDM2 axis Liu, Rui Zhou, Minghui Zhang, Puwen Zhao, Yulin Zhang, Yujie J Cancer Research Paper Growing evidence has demonstrated that in tumor progression, circular RNAs (circRNAs) play important roles. However, the roles of circRNAs in nasopharyngeal carcinoma (NPC) have not been fully elucidated. In this study, it was demonstrated that that hsa_circ_0033074 (circSERPINA3) expression was found to be significantly upregulated in NPC tissues and cell lines. CircSERPINA3 inhibition significantly attenuated the invasion and proliferation abilities of NPC cells. The mechanism by which circSERPINA3 interacted with miR-944 was identified and MDM2 was demonstrated to function as a target gene of miR-944. Rescue experiments showed that miR-944 inhibitors or MDM2 overexpression reserved the effects of circSERPINA3 knockdown on NPC progression. Therefore, our study uncovered the circSERPINA3/miR-944/MDM2 axis in NPC, which may be a potential NPC therapeutic target. Ivyspring International Publisher 2020-04-06 /pmc/articles/PMC7171482/ /pubmed/32328195 http://dx.doi.org/10.7150/jca.42799 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Liu, Rui
Zhou, Minghui
Zhang, Puwen
Zhao, Yulin
Zhang, Yujie
Cell proliferation and invasion is promoted by circSERPINA3 in nasopharyngeal carcinoma by regulating miR-944/MDM2 axis
title Cell proliferation and invasion is promoted by circSERPINA3 in nasopharyngeal carcinoma by regulating miR-944/MDM2 axis
title_full Cell proliferation and invasion is promoted by circSERPINA3 in nasopharyngeal carcinoma by regulating miR-944/MDM2 axis
title_fullStr Cell proliferation and invasion is promoted by circSERPINA3 in nasopharyngeal carcinoma by regulating miR-944/MDM2 axis
title_full_unstemmed Cell proliferation and invasion is promoted by circSERPINA3 in nasopharyngeal carcinoma by regulating miR-944/MDM2 axis
title_short Cell proliferation and invasion is promoted by circSERPINA3 in nasopharyngeal carcinoma by regulating miR-944/MDM2 axis
title_sort cell proliferation and invasion is promoted by circserpina3 in nasopharyngeal carcinoma by regulating mir-944/mdm2 axis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171482/
https://www.ncbi.nlm.nih.gov/pubmed/32328195
http://dx.doi.org/10.7150/jca.42799
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