Cargando…

Integrin αvβ8 serves as a Novel Marker of Poor Prognosis in Colon Carcinoma and Regulates Cell Invasiveness through the Activation of TGF-β1

Integrin αvβ8 expressed on tumor cells executes crucial regulatory functions during cell adhesion in the tumor microenvironment and supports the activation of TGF-β1. This study aimed to investigate the expression of integrin αvβ8 and its clinical significance in colon cancer, in addition to its inf...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Mingliang, Niu, Jun, Wang, Jinshen, Gao, Huijie, Shahbaz, Muhammad, Niu, Zhengchuan, Li, Zequn, Zou, Xueqing, Liang, Benjia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171496/ https://www.ncbi.nlm.nih.gov/pubmed/32328185 http://dx.doi.org/10.7150/jca.43826

Ejemplares similares

Integrin β6 serves as an immunohistochemical marker for lymph node metastasis and promotes cell invasiveness in cholangiocarcinoma
por: Li, Zequn, et al.
Publicado: (2016)

Protein expression of eIF4E and integrin αvβ6 in colon cancer can predict clinical significance, reveal their correlation and imply possible mechanism of interaction
por: Niu, Zhengchuan, et al.
Publicado: (2014)

Tumor specific delivery and therapy mediate by integrin β6-target immunoliposomes for β6-siRNA in colon carcinoma
por: Song, Liu, et al.
Publicado: (2016)

Integrin αvβ6 and transcriptional factor Ets-1 act as prognostic indicators in colorectal cancer
por: Peng, Cheng, et al.
Publicado: (2014)

Integrin αvβ6 plays a bi-directional regulation role between colon cancer cells and cancer-associated fibroblasts
por: Peng, Cheng, et al.
Publicado: (2018)

Norcantharidin Suppresses Colon Cancer Cell Epithelial-Mesenchymal Transition by Inhibiting the αvβ6-ERK-Ets1 Signaling Pathway
por: Peng, Cheng, et al.
Publicado: (2016)

Integrin-β6 Serves as a Potential Prognostic Serum Biomarker for Gastric Cancer
por: Li, Zequn, et al.
Publicado: (2021)

Magnesium isoglycyrrhizinate has hepatoprotective effects in an oxaliplatin-induced model of liver injury
por: Zou, Xueqing, et al.
Publicado: (2018)

β(6)-Integrin Serves as a Potential Serum Marker for Diagnosis and Prognosis of Pancreatic Adenocarcinoma
por: Lenggenhager, Daniela, et al.
Publicado: (2021)

Identification of integrin β6 gene promoter and analysis of its transcription regulation in colon cancer cells
por: Niu, Wei, et al.
Publicado: (2020)

TGFβ-mediated expression of TGFβ-activating integrins in SSc monocytes: disturbed activation of latent TGFβ?
por: van Caam, A., et al.
Publicado: (2020)

The clinical significance and underlying correlation of pStat-3 and integrin αvβ6 expression in gallbladder cancer
por: Enyu, Liu, et al.
Publicado: (2017)

The role of integrins in TGFβ activation in the tumour stroma
por: Khan, Zareen, et al.
Publicado: (2016)

Transketolase Serves as a Biomarker for Poor Prognosis in Human Lung Adenocarcinoma
por: Niu, Cong, et al.
Publicado: (2022)

TGFβ(1 )signaling via α(V)β(6 )integrin
por: Kracklauer, Martin P, et al.
Publicado: (2003)

Tgf-β1 expression as a biomarker of poor prognosis in prostate cancer
por: dos Reis, Sabrina Thalita, et al.
Publicado: (2011)

Targeted inactivation of β1 integrin induces β3 integrin switching, which drives breast cancer metastasis by TGF-β
por: Parvani, Jenny G., et al.
Publicado: (2013)

Humanized β2 Integrin-Expressing Hoxb8 Cells Serve as Model to Study Integrin Activation
por: Bromberger, Thomas, et al.
Publicado: (2022)

Integrin α(V)β(6)-mediated activation of latent TGF-β requires the latent TGF-β binding protein-1
por: Annes, Justin P., et al.
Publicado: (2004)

Retraction: TGFβ(1 )signaling via a(V)β(6 )integrin
por: Kracklauer, Martin P, et al.
Publicado: (2004)

Inhibition of Integrin αvβ6 Activation of TGF‐β Attenuates Tendinopathy
por: Wang, Xiao, et al.
Publicado: (2022)

Integrin-Mediated TGFβ Activation Modulates the Tumour Microenvironment
por: Brown, Nicholas F., et al.
Publicado: (2019)

Correction for Targeted inactivation of β1 integrin induces β3 integrin switching, which drives breast cancer metastasis by TGF-β
Publicado: (2014)

SERPINB3 is associated with TGF-β1 and cytoplasmic β-catenin expression in hepatocellular carcinomas with poor prognosis
por: Turato, C, et al.
Publicado: (2014)

Absence of integrin-mediated TGFβ1 activation in vivo recapitulates the phenotype of TGFβ1-null mice
por: Yang, Zhiwei, et al.
Publicado: (2007)

αvβ3 Integrin induces partial EMT independent of TGF-β signaling
por: Kariya, Yoshinobu, et al.
Publicado: (2021)

ARL9 is upregulated and serves as a biomarker for a poor prognosis in colon adenocarcinoma
por: Yang, Hai-deng, et al.
Publicado: (2023)

A specialized integrin-binding motif enables proTGF-β2 activation by integrin αVβ6 but not αVβ8
por: Le, Viet Q., et al.
Publicado: (2023)

Aberrant Scinderin Expression Correlates With Liver Metastasis and Poor Prognosis in Colorectal Cancer
por: Lin, Qi, et al.
Publicado: (2019)

Hypermethylation of the TGF-β target, ABCA1 is associated with poor prognosis in ovarian cancer patients
por: Chou, Jian-Liang, et al.
Publicado: (2015)

Co-expression of LASS2 and TGF-β1 predicts poor prognosis in hepatocellular carcinoma
por: Ruan, Haoyu, et al.
Publicado: (2016)

High TGF-β1 expression predicts poor disease prognosis in hepatocellular carcinoma patients
por: Peng, Li, et al.
Publicado: (2017)

RECK-Mediated β1-Integrin Regulation by TGF-β1 Is Critical for Wound Contraction in Mice
por: Gutiérrez, Jaime, et al.
Publicado: (2015)

Specificity of TGF-β1 signal designated by LRRC33 and integrin α(V)β(8)
por: Duan, Zelin, et al.
Publicado: (2022)

Distinct pathological changes of osteochondral units in early OVX-OA involving TGF-β signaling
por: Yang, Zihuan, et al.
Publicado: (2022)

Integrin αvβ6-associated ERK2 mediates MMP-9 secretion in colon cancer cells
por: Gu, X, et al.
Publicado: (2002)

aV integrins and TGF-β-induced EMT: a circle of regulation
por: Mamuya, Fahmy A, et al.
Publicado: (2012)

Regulation of TGFβ in the immune system: An emerging role for integrins and dendritic cells
por: Worthington, John J., et al.
Publicado: (2012)

Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway
por: Rapisarda, Valentina, et al.
Publicado: (2017)

New tools to study the interaction between integrins and latent TGFβ1
por: Bachmann, Michael, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_6ch6dtdtseh8mgkso8dggs9k78