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Evaluation inflammatory markers of hemogram parameters in primary ovarian insufficiency
OBJECTIVE: In most of primary ovarian insufficiency (POI) cases, etiologic factors have not been fully elucidated. Recent studies have revealed that inflammatory agents play an important role in the etiopathogenesis of POI. Therefore, the aim of this study was to investigate the role of inflammatory...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Galenos Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171537/ https://www.ncbi.nlm.nih.gov/pubmed/32341824 http://dx.doi.org/10.4274/tjod.galenos.2019.09476 |
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author | Demir, Bülent Sarıdaş Demir, Süreyya Özkan Karacaer, Kübra Paşa, Semir Sılan, Fatma |
author_facet | Demir, Bülent Sarıdaş Demir, Süreyya Özkan Karacaer, Kübra Paşa, Semir Sılan, Fatma |
author_sort | Demir, Bülent |
collection | PubMed |
description | OBJECTIVE: In most of primary ovarian insufficiency (POI) cases, etiologic factors have not been fully elucidated. Recent studies have revealed that inflammatory agents play an important role in the etiopathogenesis of POI. Therefore, the aim of this study was to investigate the role of inflammatory markers of hemogram parameters in POI. MATERIALS AND METHODS: The study compared 47 healthy women and 47 women diagnosed as having POI retrospectively by scanning electronic and written recording systems. Complete blood counts, day-3 hormone profiles levels of all subjects were analyzed. The neutrophil-lymphocyte ratio (NLR), red cell distribution width (RDW), platelet ratio (RPR), platelet lymphocyte ratio (PLR), and mean platelet volume (MPV) mean platelet lymphocyte ratio (MPLR) were calculated from the complete blood count parameters. RESULTS: White blood cell and MPV values, platelet, and lymphocyte counts were significantly higher in the POI patients (p<0.001, p=0.042, p=0.038, p=0.049, respectively), RPR was significantly lower than the control group (p=0.011), but there were no significant differences in hemoglobin, RDW, NLR, PLR, and MPLR (p=0.454, p=0.057, p=0.635, p=0.780, p=0.126, respectively). The neutrophil count of the study group was higher than in the control group (p=0.057). Bivariate correlation analyses showed no correlations between blood parameters and hormone levels. The area under the receiver operating characteristic curve for RPR in POI was 0.652, with a threshold value 0.053, sensitivity=63% and specificity=63. CONCLUSION: Inflammatory markers of hemogram detected higher in patients with POI then control subjects. |
format | Online Article Text |
id | pubmed-7171537 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Galenos Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-71715372020-04-27 Evaluation inflammatory markers of hemogram parameters in primary ovarian insufficiency Demir, Bülent Sarıdaş Demir, Süreyya Özkan Karacaer, Kübra Paşa, Semir Sılan, Fatma Turk J Obstet Gynecol Clinical Investigation OBJECTIVE: In most of primary ovarian insufficiency (POI) cases, etiologic factors have not been fully elucidated. Recent studies have revealed that inflammatory agents play an important role in the etiopathogenesis of POI. Therefore, the aim of this study was to investigate the role of inflammatory markers of hemogram parameters in POI. MATERIALS AND METHODS: The study compared 47 healthy women and 47 women diagnosed as having POI retrospectively by scanning electronic and written recording systems. Complete blood counts, day-3 hormone profiles levels of all subjects were analyzed. The neutrophil-lymphocyte ratio (NLR), red cell distribution width (RDW), platelet ratio (RPR), platelet lymphocyte ratio (PLR), and mean platelet volume (MPV) mean platelet lymphocyte ratio (MPLR) were calculated from the complete blood count parameters. RESULTS: White blood cell and MPV values, platelet, and lymphocyte counts were significantly higher in the POI patients (p<0.001, p=0.042, p=0.038, p=0.049, respectively), RPR was significantly lower than the control group (p=0.011), but there were no significant differences in hemoglobin, RDW, NLR, PLR, and MPLR (p=0.454, p=0.057, p=0.635, p=0.780, p=0.126, respectively). The neutrophil count of the study group was higher than in the control group (p=0.057). Bivariate correlation analyses showed no correlations between blood parameters and hormone levels. The area under the receiver operating characteristic curve for RPR in POI was 0.652, with a threshold value 0.053, sensitivity=63% and specificity=63. CONCLUSION: Inflammatory markers of hemogram detected higher in patients with POI then control subjects. Galenos Publishing 2020-03 2020-04-06 /pmc/articles/PMC7171537/ /pubmed/32341824 http://dx.doi.org/10.4274/tjod.galenos.2019.09476 Text en ©Copyright 2020 by Turkish Society of Obstetrics and Gynecology | Turkish Journal of Obstetrics and Gynecology published by Galenos Publishing House. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Investigation Demir, Bülent Sarıdaş Demir, Süreyya Özkan Karacaer, Kübra Paşa, Semir Sılan, Fatma Evaluation inflammatory markers of hemogram parameters in primary ovarian insufficiency |
title | Evaluation inflammatory markers of hemogram parameters in primary ovarian insufficiency |
title_full | Evaluation inflammatory markers of hemogram parameters in primary ovarian insufficiency |
title_fullStr | Evaluation inflammatory markers of hemogram parameters in primary ovarian insufficiency |
title_full_unstemmed | Evaluation inflammatory markers of hemogram parameters in primary ovarian insufficiency |
title_short | Evaluation inflammatory markers of hemogram parameters in primary ovarian insufficiency |
title_sort | evaluation inflammatory markers of hemogram parameters in primary ovarian insufficiency |
topic | Clinical Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171537/ https://www.ncbi.nlm.nih.gov/pubmed/32341824 http://dx.doi.org/10.4274/tjod.galenos.2019.09476 |
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