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Relay Cross Metathesis for the Iterative Construction of Terpenoids and Synthesis of a Diterpene-Benzoate Macrolide of Biogenetic Relevance to the Bromophycolides
[Image: see text] We report a relay cross metathesis (ReXM) reaction for the construction of terpenoids in an iterative protocol. The protocol features the cross metathesis of a relay-actuated Δ(6,7)-functionalized C(10)-monoterpenoid alcohol with C(10)-monoterpenoid citral to form a C(15)-sesquiter...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171603/ https://www.ncbi.nlm.nih.gov/pubmed/32227974 http://dx.doi.org/10.1021/acs.orglett.0c00935 |
| Sumario: | [Image: see text] We report a relay cross metathesis (ReXM) reaction for the construction of terpenoids in an iterative protocol. The protocol features the cross metathesis of a relay-actuated Δ(6,7)-functionalized C(10)-monoterpenoid alcohol with C(10)-monoterpenoid citral to form a C(15)-sesquiterpene. Subsequent functional group manipulation allows for the method to be repeated in an iterative fashion. The method is used for the synthesis of a diterpene-benzoate macrolide of biogenetic relevance to the bromophycolide family of natural products. |
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