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Case report of a cystic parathyroidal adenoma with rapid growth induced by cinacalcet

BACKGROUND: Primary hyperparathyroidism is a rare condition of disease which can seldomly present as giant retrotrhyroideal cysts, complicating the localization of the adenoma to resect. CASE PRESENTATION: A 56-year old female presented with hypercalcaemia of 3.38 mmol/L (2.2–2.65 mmol/L) and a hist...

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Autores principales: Werner, Christoph, Lupp, Amelie, Mtuka-Pardon, Gabriele, Kloos, Christof, Wolf, Gunter, Aschenbach, René, Biermann, Anika, Freesmeyer, Martin, Seifert, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171747/
https://www.ncbi.nlm.nih.gov/pubmed/32312250
http://dx.doi.org/10.1186/s12902-020-0532-7
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author Werner, Christoph
Lupp, Amelie
Mtuka-Pardon, Gabriele
Kloos, Christof
Wolf, Gunter
Aschenbach, René
Biermann, Anika
Freesmeyer, Martin
Seifert, Philipp
author_facet Werner, Christoph
Lupp, Amelie
Mtuka-Pardon, Gabriele
Kloos, Christof
Wolf, Gunter
Aschenbach, René
Biermann, Anika
Freesmeyer, Martin
Seifert, Philipp
author_sort Werner, Christoph
collection PubMed
description BACKGROUND: Primary hyperparathyroidism is a rare condition of disease which can seldomly present as giant retrotrhyroideal cysts, complicating the localization of the adenoma to resect. CASE PRESENTATION: A 56-year old female presented with hypercalcaemia of 3.38 mmol/L (2.2–2.65 mmol/L) and a history of breast cancer. A fast growing cystic parathyroidal adenoma was diagnosed by a multimodal approach including comprehensive diagnostic imaging (ultrasonography, scintigraphies, dynamic MRI) and cytopathological investigations after ultrasonography-guided puncture. The patient was cured by surgical extraction of the whole adenoma. In retrospect, the rapid growth was most likely induced by cinacalcet (initially 30 mg/d, later 60 mg/d) therapy which the patient received for few months only. Primary hyperparathyroidism was ascertained because surgical removal of the solitary adenoma cured the patient. Furthermore, there was no relevant renal insufficiency or history of prolonged calcium-level deregulation. CONCLUSIONS: This phenomenon of cystic degeneration of parathyroidal adenoma under therapy with cinacalcet has previously been described in secondary hyperparathyroidism, but not in primary hyperparathyroidism and should be considered in diagnostic approach.
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spelling pubmed-71717472020-04-24 Case report of a cystic parathyroidal adenoma with rapid growth induced by cinacalcet Werner, Christoph Lupp, Amelie Mtuka-Pardon, Gabriele Kloos, Christof Wolf, Gunter Aschenbach, René Biermann, Anika Freesmeyer, Martin Seifert, Philipp BMC Endocr Disord Case Report BACKGROUND: Primary hyperparathyroidism is a rare condition of disease which can seldomly present as giant retrotrhyroideal cysts, complicating the localization of the adenoma to resect. CASE PRESENTATION: A 56-year old female presented with hypercalcaemia of 3.38 mmol/L (2.2–2.65 mmol/L) and a history of breast cancer. A fast growing cystic parathyroidal adenoma was diagnosed by a multimodal approach including comprehensive diagnostic imaging (ultrasonography, scintigraphies, dynamic MRI) and cytopathological investigations after ultrasonography-guided puncture. The patient was cured by surgical extraction of the whole adenoma. In retrospect, the rapid growth was most likely induced by cinacalcet (initially 30 mg/d, later 60 mg/d) therapy which the patient received for few months only. Primary hyperparathyroidism was ascertained because surgical removal of the solitary adenoma cured the patient. Furthermore, there was no relevant renal insufficiency or history of prolonged calcium-level deregulation. CONCLUSIONS: This phenomenon of cystic degeneration of parathyroidal adenoma under therapy with cinacalcet has previously been described in secondary hyperparathyroidism, but not in primary hyperparathyroidism and should be considered in diagnostic approach. BioMed Central 2020-04-20 /pmc/articles/PMC7171747/ /pubmed/32312250 http://dx.doi.org/10.1186/s12902-020-0532-7 Text en © The Author(s). 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Werner, Christoph
Lupp, Amelie
Mtuka-Pardon, Gabriele
Kloos, Christof
Wolf, Gunter
Aschenbach, René
Biermann, Anika
Freesmeyer, Martin
Seifert, Philipp
Case report of a cystic parathyroidal adenoma with rapid growth induced by cinacalcet
title Case report of a cystic parathyroidal adenoma with rapid growth induced by cinacalcet
title_full Case report of a cystic parathyroidal adenoma with rapid growth induced by cinacalcet
title_fullStr Case report of a cystic parathyroidal adenoma with rapid growth induced by cinacalcet
title_full_unstemmed Case report of a cystic parathyroidal adenoma with rapid growth induced by cinacalcet
title_short Case report of a cystic parathyroidal adenoma with rapid growth induced by cinacalcet
title_sort case report of a cystic parathyroidal adenoma with rapid growth induced by cinacalcet
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171747/
https://www.ncbi.nlm.nih.gov/pubmed/32312250
http://dx.doi.org/10.1186/s12902-020-0532-7
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