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Case Report: Invasive Non Type b Haemophilus influenzae in Immunocompromised Children
Case series Patients: Male, 2-year-old • Male, 4-year-old • Male, 2-year-old Final Diagnosis: Immunodeficiency and Hib Symptoms: Fever • lethargy • reduced food intake Medication: — Clinical Procedure: — Specialty: Immunology OBJECTIVE: Unusual clinical course BACKGROUND: Implementation of the Haemo...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172003/ https://www.ncbi.nlm.nih.gov/pubmed/32277070 http://dx.doi.org/10.12659/AJCR.920853 |
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author | Gozum, Giselle Gayle Tatarina-Nulman, Oksana John, Minnie |
author_facet | Gozum, Giselle Gayle Tatarina-Nulman, Oksana John, Minnie |
author_sort | Gozum, Giselle Gayle |
collection | PubMed |
description | Case series Patients: Male, 2-year-old • Male, 4-year-old • Male, 2-year-old Final Diagnosis: Immunodeficiency and Hib Symptoms: Fever • lethargy • reduced food intake Medication: — Clinical Procedure: — Specialty: Immunology OBJECTIVE: Unusual clinical course BACKGROUND: Implementation of the Haemophilus influenzae type b (Hib) conjugate vaccine brought about a reduction in the number of cases and morbidity from type B but increase in nontypeable strain infections. CASE REPORTS: We had 3 cases of invasive non type Hemophilus influenzae (NTBHI) in immunocompromised children. The first was a fully vaccinated 2-year-old male with a history of pseudomonas sepsis who presented with 1 day of lethargy, fever, vomiting, and diarrhea. Blood culture was positive for Haemophilus influenzae e and cerebrospinal fluid (CSF) confirmed meningitis. Immune deficiency and genetic testing revealed X-linked agammaglobulinemia. The second case was a 4-year-old male, status post liver transplantation, who presented with pneumonia, with positive blood culture for H. influenzae. The last case was of a 2-year-old male with H. influenzae bio-type VI in both blood and CSF cultures, who on follow-up was confirmed to have hypogammaglobulinemia. CONCLUSIONS: For children diagnosed with an invasive disease caused by NTBHI, a workup for immunodeficiency could be warranted. With the appearance of nontype b serotypes, more studies are needed to determine epidemiology and virulence of these types, and their clinical relevance – perhaps developing a new vaccine to cover nontype b stereotypes, especially for immunodeficient patients. |
format | Online Article Text |
id | pubmed-7172003 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71720032020-04-28 Case Report: Invasive Non Type b Haemophilus influenzae in Immunocompromised Children Gozum, Giselle Gayle Tatarina-Nulman, Oksana John, Minnie Am J Case Rep Articles Case series Patients: Male, 2-year-old • Male, 4-year-old • Male, 2-year-old Final Diagnosis: Immunodeficiency and Hib Symptoms: Fever • lethargy • reduced food intake Medication: — Clinical Procedure: — Specialty: Immunology OBJECTIVE: Unusual clinical course BACKGROUND: Implementation of the Haemophilus influenzae type b (Hib) conjugate vaccine brought about a reduction in the number of cases and morbidity from type B but increase in nontypeable strain infections. CASE REPORTS: We had 3 cases of invasive non type Hemophilus influenzae (NTBHI) in immunocompromised children. The first was a fully vaccinated 2-year-old male with a history of pseudomonas sepsis who presented with 1 day of lethargy, fever, vomiting, and diarrhea. Blood culture was positive for Haemophilus influenzae e and cerebrospinal fluid (CSF) confirmed meningitis. Immune deficiency and genetic testing revealed X-linked agammaglobulinemia. The second case was a 4-year-old male, status post liver transplantation, who presented with pneumonia, with positive blood culture for H. influenzae. The last case was of a 2-year-old male with H. influenzae bio-type VI in both blood and CSF cultures, who on follow-up was confirmed to have hypogammaglobulinemia. CONCLUSIONS: For children diagnosed with an invasive disease caused by NTBHI, a workup for immunodeficiency could be warranted. With the appearance of nontype b serotypes, more studies are needed to determine epidemiology and virulence of these types, and their clinical relevance – perhaps developing a new vaccine to cover nontype b stereotypes, especially for immunodeficient patients. International Scientific Literature, Inc. 2020-04-11 /pmc/articles/PMC7172003/ /pubmed/32277070 http://dx.doi.org/10.12659/AJCR.920853 Text en © Am J Case Rep, 2020 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Articles Gozum, Giselle Gayle Tatarina-Nulman, Oksana John, Minnie Case Report: Invasive Non Type b Haemophilus influenzae in Immunocompromised Children |
title | Case Report: Invasive Non Type b Haemophilus influenzae in Immunocompromised Children |
title_full | Case Report: Invasive Non Type b Haemophilus influenzae in Immunocompromised Children |
title_fullStr | Case Report: Invasive Non Type b Haemophilus influenzae in Immunocompromised Children |
title_full_unstemmed | Case Report: Invasive Non Type b Haemophilus influenzae in Immunocompromised Children |
title_short | Case Report: Invasive Non Type b Haemophilus influenzae in Immunocompromised Children |
title_sort | case report: invasive non type b haemophilus influenzae in immunocompromised children |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172003/ https://www.ncbi.nlm.nih.gov/pubmed/32277070 http://dx.doi.org/10.12659/AJCR.920853 |
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