Cargando…

Case Report: Invasive Non Type b Haemophilus influenzae in Immunocompromised Children

Case series Patients: Male, 2-year-old • Male, 4-year-old • Male, 2-year-old Final Diagnosis: Immunodeficiency and Hib Symptoms: Fever • lethargy • reduced food intake Medication: — Clinical Procedure: — Specialty: Immunology OBJECTIVE: Unusual clinical course BACKGROUND: Implementation of the Haemo...

Descripción completa

Detalles Bibliográficos
Autores principales: Gozum, Giselle Gayle, Tatarina-Nulman, Oksana, John, Minnie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172003/
https://www.ncbi.nlm.nih.gov/pubmed/32277070
http://dx.doi.org/10.12659/AJCR.920853
_version_ 1783524174468218880
author Gozum, Giselle Gayle
Tatarina-Nulman, Oksana
John, Minnie
author_facet Gozum, Giselle Gayle
Tatarina-Nulman, Oksana
John, Minnie
author_sort Gozum, Giselle Gayle
collection PubMed
description Case series Patients: Male, 2-year-old • Male, 4-year-old • Male, 2-year-old Final Diagnosis: Immunodeficiency and Hib Symptoms: Fever • lethargy • reduced food intake Medication: — Clinical Procedure: — Specialty: Immunology OBJECTIVE: Unusual clinical course BACKGROUND: Implementation of the Haemophilus influenzae type b (Hib) conjugate vaccine brought about a reduction in the number of cases and morbidity from type B but increase in nontypeable strain infections. CASE REPORTS: We had 3 cases of invasive non type Hemophilus influenzae (NTBHI) in immunocompromised children. The first was a fully vaccinated 2-year-old male with a history of pseudomonas sepsis who presented with 1 day of lethargy, fever, vomiting, and diarrhea. Blood culture was positive for Haemophilus influenzae e and cerebrospinal fluid (CSF) confirmed meningitis. Immune deficiency and genetic testing revealed X-linked agammaglobulinemia. The second case was a 4-year-old male, status post liver transplantation, who presented with pneumonia, with positive blood culture for H. influenzae. The last case was of a 2-year-old male with H. influenzae bio-type VI in both blood and CSF cultures, who on follow-up was confirmed to have hypogammaglobulinemia. CONCLUSIONS: For children diagnosed with an invasive disease caused by NTBHI, a workup for immunodeficiency could be warranted. With the appearance of nontype b serotypes, more studies are needed to determine epidemiology and virulence of these types, and their clinical relevance – perhaps developing a new vaccine to cover nontype b stereotypes, especially for immunodeficient patients.
format Online
Article
Text
id pubmed-7172003
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher International Scientific Literature, Inc.
record_format MEDLINE/PubMed
spelling pubmed-71720032020-04-28 Case Report: Invasive Non Type b Haemophilus influenzae in Immunocompromised Children Gozum, Giselle Gayle Tatarina-Nulman, Oksana John, Minnie Am J Case Rep Articles Case series Patients: Male, 2-year-old • Male, 4-year-old • Male, 2-year-old Final Diagnosis: Immunodeficiency and Hib Symptoms: Fever • lethargy • reduced food intake Medication: — Clinical Procedure: — Specialty: Immunology OBJECTIVE: Unusual clinical course BACKGROUND: Implementation of the Haemophilus influenzae type b (Hib) conjugate vaccine brought about a reduction in the number of cases and morbidity from type B but increase in nontypeable strain infections. CASE REPORTS: We had 3 cases of invasive non type Hemophilus influenzae (NTBHI) in immunocompromised children. The first was a fully vaccinated 2-year-old male with a history of pseudomonas sepsis who presented with 1 day of lethargy, fever, vomiting, and diarrhea. Blood culture was positive for Haemophilus influenzae e and cerebrospinal fluid (CSF) confirmed meningitis. Immune deficiency and genetic testing revealed X-linked agammaglobulinemia. The second case was a 4-year-old male, status post liver transplantation, who presented with pneumonia, with positive blood culture for H. influenzae. The last case was of a 2-year-old male with H. influenzae bio-type VI in both blood and CSF cultures, who on follow-up was confirmed to have hypogammaglobulinemia. CONCLUSIONS: For children diagnosed with an invasive disease caused by NTBHI, a workup for immunodeficiency could be warranted. With the appearance of nontype b serotypes, more studies are needed to determine epidemiology and virulence of these types, and their clinical relevance – perhaps developing a new vaccine to cover nontype b stereotypes, especially for immunodeficient patients. International Scientific Literature, Inc. 2020-04-11 /pmc/articles/PMC7172003/ /pubmed/32277070 http://dx.doi.org/10.12659/AJCR.920853 Text en © Am J Case Rep, 2020 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Articles
Gozum, Giselle Gayle
Tatarina-Nulman, Oksana
John, Minnie
Case Report: Invasive Non Type b Haemophilus influenzae in Immunocompromised Children
title Case Report: Invasive Non Type b Haemophilus influenzae in Immunocompromised Children
title_full Case Report: Invasive Non Type b Haemophilus influenzae in Immunocompromised Children
title_fullStr Case Report: Invasive Non Type b Haemophilus influenzae in Immunocompromised Children
title_full_unstemmed Case Report: Invasive Non Type b Haemophilus influenzae in Immunocompromised Children
title_short Case Report: Invasive Non Type b Haemophilus influenzae in Immunocompromised Children
title_sort case report: invasive non type b haemophilus influenzae in immunocompromised children
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172003/
https://www.ncbi.nlm.nih.gov/pubmed/32277070
http://dx.doi.org/10.12659/AJCR.920853
work_keys_str_mv AT gozumgisellegayle casereportinvasivenontypebhaemophilusinfluenzaeinimmunocompromisedchildren
AT tatarinanulmanoksana casereportinvasivenontypebhaemophilusinfluenzaeinimmunocompromisedchildren
AT johnminnie casereportinvasivenontypebhaemophilusinfluenzaeinimmunocompromisedchildren