Evasion of early innate immune response by 2′-O-methylation of dengue genomic RNA

Dengue virus (DENV) is the most prevalent mosquito-borne virus pathogen in humans. There is currently no antiviral therapeutic or widely available vaccine against dengue infection. The DENV RNA genome is methylated on its 5′ cap by its NS5 protein. DENV bearing a single E216A point mutation in NS5 l...

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Detalles Bibliográficos
Autores principales: Chang, David C., Hoang, Long T., Mohamed Naim, Ahmad Nazri, Dong, Hongping, Schreiber, Mark J., Hibberd, Martin L., Tan, Min Jie Alvin, Shi, Pei-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172056/
https://www.ncbi.nlm.nih.gov/pubmed/27716465
http://dx.doi.org/10.1016/j.virol.2016.09.022

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