Solid phase synthesis and biological evaluation of probestin as an angiogenesis inhibitor

Probestin is a potent aminopeptidase N (APN) inhibitor originally isolated from the bacterial culture broth. Here, we report probestin synthesis by solid phase peptide synthesis (SPPS) method and evaluated its activity to inhibit angiogenesis using a chicken embryo chorioallantoic membrane (CAM) ass...

Descripción completa

Detalles Bibliográficos
Autores principales: Pathuri, Gopal, Thorpe, Jessica E., Disch, Bryan C., Bailey-Downs, Lora C., Ihnat, Michael A., Gali, Hariprasad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172075/
https://www.ncbi.nlm.nih.gov/pubmed/23664876
http://dx.doi.org/10.1016/j.bmcl.2013.04.031
_version_ 1783524184418156544
author Pathuri, Gopal
Thorpe, Jessica E.
Disch, Bryan C.
Bailey-Downs, Lora C.
Ihnat, Michael A.
Gali, Hariprasad
author_facet Pathuri, Gopal
Thorpe, Jessica E.
Disch, Bryan C.
Bailey-Downs, Lora C.
Ihnat, Michael A.
Gali, Hariprasad
author_sort Pathuri, Gopal
collection PubMed
description Probestin is a potent aminopeptidase N (APN) inhibitor originally isolated from the bacterial culture broth. Here, we report probestin synthesis by solid phase peptide synthesis (SPPS) method and evaluated its activity to inhibit angiogenesis using a chicken embryo chorioallantoic membrane (CAM) assay and a CAM tumor xenograft model. Results from these studies demonstrate that probestin inhibits the angiogenic activity and tumor growth.
format Online
Article
Text
id pubmed-7172075
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Elsevier Ltd.
record_format MEDLINE/PubMed
spelling pubmed-71720752020-04-22 Solid phase synthesis and biological evaluation of probestin as an angiogenesis inhibitor Pathuri, Gopal Thorpe, Jessica E. Disch, Bryan C. Bailey-Downs, Lora C. Ihnat, Michael A. Gali, Hariprasad Bioorg Med Chem Lett Article Probestin is a potent aminopeptidase N (APN) inhibitor originally isolated from the bacterial culture broth. Here, we report probestin synthesis by solid phase peptide synthesis (SPPS) method and evaluated its activity to inhibit angiogenesis using a chicken embryo chorioallantoic membrane (CAM) assay and a CAM tumor xenograft model. Results from these studies demonstrate that probestin inhibits the angiogenic activity and tumor growth. Elsevier Ltd. 2013-06-15 2013-04-23 /pmc/articles/PMC7172075/ /pubmed/23664876 http://dx.doi.org/10.1016/j.bmcl.2013.04.031 Text en Copyright © 2013 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Pathuri, Gopal
Thorpe, Jessica E.
Disch, Bryan C.
Bailey-Downs, Lora C.
Ihnat, Michael A.
Gali, Hariprasad
Solid phase synthesis and biological evaluation of probestin as an angiogenesis inhibitor
title Solid phase synthesis and biological evaluation of probestin as an angiogenesis inhibitor
title_full Solid phase synthesis and biological evaluation of probestin as an angiogenesis inhibitor
title_fullStr Solid phase synthesis and biological evaluation of probestin as an angiogenesis inhibitor
title_full_unstemmed Solid phase synthesis and biological evaluation of probestin as an angiogenesis inhibitor
title_short Solid phase synthesis and biological evaluation of probestin as an angiogenesis inhibitor
title_sort solid phase synthesis and biological evaluation of probestin as an angiogenesis inhibitor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172075/
https://www.ncbi.nlm.nih.gov/pubmed/23664876
http://dx.doi.org/10.1016/j.bmcl.2013.04.031
work_keys_str_mv AT pathurigopal solidphasesynthesisandbiologicalevaluationofprobestinasanangiogenesisinhibitor
AT thorpejessicae solidphasesynthesisandbiologicalevaluationofprobestinasanangiogenesisinhibitor
AT dischbryanc solidphasesynthesisandbiologicalevaluationofprobestinasanangiogenesisinhibitor
AT baileydownslorac solidphasesynthesisandbiologicalevaluationofprobestinasanangiogenesisinhibitor
AT ihnatmichaela solidphasesynthesisandbiologicalevaluationofprobestinasanangiogenesisinhibitor
AT galihariprasad solidphasesynthesisandbiologicalevaluationofprobestinasanangiogenesisinhibitor

Ejemplares similares