Association between respiratory and herpes viruses on pulmonary exacerbations in cystic fibrosis patients

Respiratory viruses discovered in the 21st century and human herpes viruses (N = 13) were seldom (4/50) detected in our cystic fibrosis patients although exacerbation frequency (7.75 ± 2.9/a versus 4.45 ± 2.1/a; p = 0.03) and colonization with Aspergillus fumigatus (RR: 2.6; CI95: 1.8–3.7), Pseudomo...

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Detalles Bibliográficos
Autores principales: Scheithauer, Simone, Haase, Gerhard, Häusler, Martin, Lemmen, Sebastian, Ritter, Klaus, Kleines, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Cystic Fibrosis Society. Published by Elsevier B.V. 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172122/
https://www.ncbi.nlm.nih.gov/pubmed/20199892
http://dx.doi.org/10.1016/j.jcf.2010.02.002
Descripción
Sumario:Respiratory viruses discovered in the 21st century and human herpes viruses (N = 13) were seldom (4/50) detected in our cystic fibrosis patients although exacerbation frequency (7.75 ± 2.9/a versus 4.45 ± 2.1/a; p = 0.03) and colonization with Aspergillus fumigatus (RR: 2.6; CI95: 1.8–3.7), Pseudomonas aeruginosa (RR: 1.84; CI95: 1.4–2.4), and Staphylococcus aureus (RR: 1.5; CI95: 1.2–1.9) including MRSA (RR: 4.6; CI95: 1.3–16.6) were associated with virus positivity. Further studies should clarify whether this finding reflects non-specific colonization (human Bocavirus) or reactivation (Epstein-Barr virus) or rather an acceleration of lung tissue inflammation.

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