Association between respiratory and herpes viruses on pulmonary exacerbations in cystic fibrosis patients

Respiratory viruses discovered in the 21st century and human herpes viruses (N = 13) were seldom (4/50) detected in our cystic fibrosis patients although exacerbation frequency (7.75 ± 2.9/a versus 4.45 ± 2.1/a; p = 0.03) and colonization with Aspergillus fumigatus (RR: 2.6; CI95: 1.8–3.7), Pseudomo...

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Autores principales: Scheithauer, Simone, Haase, Gerhard, Häusler, Martin, Lemmen, Sebastian, Ritter, Klaus, Kleines, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Cystic Fibrosis Society. Published by Elsevier B.V. 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172122/
https://www.ncbi.nlm.nih.gov/pubmed/20199892
http://dx.doi.org/10.1016/j.jcf.2010.02.002
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author Scheithauer, Simone
Haase, Gerhard
Häusler, Martin
Lemmen, Sebastian
Ritter, Klaus
Kleines, Michael
author_facet Scheithauer, Simone
Haase, Gerhard
Häusler, Martin
Lemmen, Sebastian
Ritter, Klaus
Kleines, Michael
author_sort Scheithauer, Simone
collection PubMed
description Respiratory viruses discovered in the 21st century and human herpes viruses (N = 13) were seldom (4/50) detected in our cystic fibrosis patients although exacerbation frequency (7.75 ± 2.9/a versus 4.45 ± 2.1/a; p = 0.03) and colonization with Aspergillus fumigatus (RR: 2.6; CI95: 1.8–3.7), Pseudomonas aeruginosa (RR: 1.84; CI95: 1.4–2.4), and Staphylococcus aureus (RR: 1.5; CI95: 1.2–1.9) including MRSA (RR: 4.6; CI95: 1.3–16.6) were associated with virus positivity. Further studies should clarify whether this finding reflects non-specific colonization (human Bocavirus) or reactivation (Epstein-Barr virus) or rather an acceleration of lung tissue inflammation.
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spelling pubmed-71721222020-04-22 Association between respiratory and herpes viruses on pulmonary exacerbations in cystic fibrosis patients Scheithauer, Simone Haase, Gerhard Häusler, Martin Lemmen, Sebastian Ritter, Klaus Kleines, Michael J Cyst Fibros Article Respiratory viruses discovered in the 21st century and human herpes viruses (N = 13) were seldom (4/50) detected in our cystic fibrosis patients although exacerbation frequency (7.75 ± 2.9/a versus 4.45 ± 2.1/a; p = 0.03) and colonization with Aspergillus fumigatus (RR: 2.6; CI95: 1.8–3.7), Pseudomonas aeruginosa (RR: 1.84; CI95: 1.4–2.4), and Staphylococcus aureus (RR: 1.5; CI95: 1.2–1.9) including MRSA (RR: 4.6; CI95: 1.3–16.6) were associated with virus positivity. Further studies should clarify whether this finding reflects non-specific colonization (human Bocavirus) or reactivation (Epstein-Barr virus) or rather an acceleration of lung tissue inflammation. European Cystic Fibrosis Society. Published by Elsevier B.V. 2010-05 2010-03-02 /pmc/articles/PMC7172122/ /pubmed/20199892 http://dx.doi.org/10.1016/j.jcf.2010.02.002 Text en Copyright © 2010 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Scheithauer, Simone
Haase, Gerhard
Häusler, Martin
Lemmen, Sebastian
Ritter, Klaus
Kleines, Michael
Association between respiratory and herpes viruses on pulmonary exacerbations in cystic fibrosis patients
title Association between respiratory and herpes viruses on pulmonary exacerbations in cystic fibrosis patients
title_full Association between respiratory and herpes viruses on pulmonary exacerbations in cystic fibrosis patients
title_fullStr Association between respiratory and herpes viruses on pulmonary exacerbations in cystic fibrosis patients
title_full_unstemmed Association between respiratory and herpes viruses on pulmonary exacerbations in cystic fibrosis patients
title_short Association between respiratory and herpes viruses on pulmonary exacerbations in cystic fibrosis patients
title_sort association between respiratory and herpes viruses on pulmonary exacerbations in cystic fibrosis patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172122/
https://www.ncbi.nlm.nih.gov/pubmed/20199892
http://dx.doi.org/10.1016/j.jcf.2010.02.002
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