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Risk of zoonotic transmission of HEV from rabbits

Hepatitis E virus strains from rabbits indicate that these mammals may be a reservoir for HEVs that cause infection in humans. Further issues remain to be clarified, including whether the genotype of rabbit HEV differs from human and swine HEV genotype 3 and whether rabbit HEV can infect human and o...

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Autores principales: Lhomme, Sébastien, Dubois, Martine, Abravanel, Florence, Top, Sokunthea, Bertagnoli, Stéphane, Guerin, Jean-Luc, Izopet, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172140/
https://www.ncbi.nlm.nih.gov/pubmed/23474012
http://dx.doi.org/10.1016/j.jcv.2013.02.006
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author Lhomme, Sébastien
Dubois, Martine
Abravanel, Florence
Top, Sokunthea
Bertagnoli, Stéphane
Guerin, Jean-Luc
Izopet, Jacques
author_facet Lhomme, Sébastien
Dubois, Martine
Abravanel, Florence
Top, Sokunthea
Bertagnoli, Stéphane
Guerin, Jean-Luc
Izopet, Jacques
author_sort Lhomme, Sébastien
collection PubMed
description Hepatitis E virus strains from rabbits indicate that these mammals may be a reservoir for HEVs that cause infection in humans. Further issues remain to be clarified, including whether the genotype of rabbit HEV differs from human and swine HEV genotype 3 and whether rabbit HEV can infect human and other animals. HEV was found in farmed rabbits in several geographic areas of China, in USA and more recently in France. The prevalence of antibodies against HEV was 36%, 57% and 55% in rabbits from Virginia (USA), Gansu Province and Beijing (China), respectively. HEV RNA was detected in 16.5% of serum samples from farmed rabbits in Virginia, 7.5% in Gansu Province and 7.0% in Beijing. HEV RNA was detected in 7% of bile samples from farmed rabbits and in 23% of liver samples from wild rabbits in France. The full-length genomic sequences analysis indicates that all the rabbit strains belong to the same clade. Nucleotide sequences were 72.2–78.2% identical to HEV genotypes 1–4. Comparison with HEV sequences of human strains circulating in France and reference sequences identified a human strain closely related to rabbit HEV. A 93-nucleotide insertion in the X domain of the ORF1 of the human strain and in all the rabbit HEV strains was found. Moreover, the ability of rabbit HEV to cause cross-species infection in a pig model has recently been demonstrated. Rabbit HEV can replicate efficiently in human cell lines. Collectively, these data support the possibility of zoonotic transmission of HEV from rabbits.
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spelling pubmed-71721402020-04-22 Risk of zoonotic transmission of HEV from rabbits Lhomme, Sébastien Dubois, Martine Abravanel, Florence Top, Sokunthea Bertagnoli, Stéphane Guerin, Jean-Luc Izopet, Jacques J Clin Virol Review Hepatitis E virus strains from rabbits indicate that these mammals may be a reservoir for HEVs that cause infection in humans. Further issues remain to be clarified, including whether the genotype of rabbit HEV differs from human and swine HEV genotype 3 and whether rabbit HEV can infect human and other animals. HEV was found in farmed rabbits in several geographic areas of China, in USA and more recently in France. The prevalence of antibodies against HEV was 36%, 57% and 55% in rabbits from Virginia (USA), Gansu Province and Beijing (China), respectively. HEV RNA was detected in 16.5% of serum samples from farmed rabbits in Virginia, 7.5% in Gansu Province and 7.0% in Beijing. HEV RNA was detected in 7% of bile samples from farmed rabbits and in 23% of liver samples from wild rabbits in France. The full-length genomic sequences analysis indicates that all the rabbit strains belong to the same clade. Nucleotide sequences were 72.2–78.2% identical to HEV genotypes 1–4. Comparison with HEV sequences of human strains circulating in France and reference sequences identified a human strain closely related to rabbit HEV. A 93-nucleotide insertion in the X domain of the ORF1 of the human strain and in all the rabbit HEV strains was found. Moreover, the ability of rabbit HEV to cause cross-species infection in a pig model has recently been demonstrated. Rabbit HEV can replicate efficiently in human cell lines. Collectively, these data support the possibility of zoonotic transmission of HEV from rabbits. Published by Elsevier B.V. 2013-10 2013-03-07 /pmc/articles/PMC7172140/ /pubmed/23474012 http://dx.doi.org/10.1016/j.jcv.2013.02.006 Text en Copyright © 2013 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Lhomme, Sébastien
Dubois, Martine
Abravanel, Florence
Top, Sokunthea
Bertagnoli, Stéphane
Guerin, Jean-Luc
Izopet, Jacques
Risk of zoonotic transmission of HEV from rabbits
title Risk of zoonotic transmission of HEV from rabbits
title_full Risk of zoonotic transmission of HEV from rabbits
title_fullStr Risk of zoonotic transmission of HEV from rabbits
title_full_unstemmed Risk of zoonotic transmission of HEV from rabbits
title_short Risk of zoonotic transmission of HEV from rabbits
title_sort risk of zoonotic transmission of hev from rabbits
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172140/
https://www.ncbi.nlm.nih.gov/pubmed/23474012
http://dx.doi.org/10.1016/j.jcv.2013.02.006
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