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Chronic, eventually fatal, Kawasaki-like disease in an adult with spondylarthropathy responding to IVIG therapy
We report on an unusual case of a 40-year-old Caucasian male displaying severe Kawasaki-like symptoms. The disease lasted for seven years before diffuse coronary aneurysms occurred, leading to the patient's death, despite ongoing treatment by intravenous immunoglobulins (IVIGs). The patient had...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Société française de rhumatologie. Published by Elsevier Masson SAS
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172168/ https://www.ncbi.nlm.nih.gov/pubmed/19464220 http://dx.doi.org/10.1016/j.jbspin.2009.01.006 |
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author | Soltner, Elise Neel, Antoine Tiab, Mourad Varin, Stéphane Cormier, Grégoire Maisonneuve, Hervé Maugars, Yves Tanguy, Gilles Hamidou, Mohamed Berthelot, Jean-Marie |
author_facet | Soltner, Elise Neel, Antoine Tiab, Mourad Varin, Stéphane Cormier, Grégoire Maisonneuve, Hervé Maugars, Yves Tanguy, Gilles Hamidou, Mohamed Berthelot, Jean-Marie |
author_sort | Soltner, Elise |
collection | PubMed |
description | We report on an unusual case of a 40-year-old Caucasian male displaying severe Kawasaki-like symptoms. The disease lasted for seven years before diffuse coronary aneurysms occurred, leading to the patient's death, despite ongoing treatment by intravenous immunoglobulins (IVIGs). The patient had also been suffering from a disabling inflammation of the spine, which was reported to have started at the onset of the disorder. Whereas neither NSAIDS, nor high doses corticosteroids, or anti-TNF drugs had a clear effect, the clinical features of spinal inflammation were highly sensitive to IVIGs, and were attributed definitively to HLA-B27-negative axial spondylarthropathy after bone scan and magnetic resonance imaging disclosed typical enthesitis of both heels and bilateral sacroiliitis. |
format | Online Article Text |
id | pubmed-7172168 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Société française de rhumatologie. Published by Elsevier Masson SAS |
record_format | MEDLINE/PubMed |
spelling | pubmed-71721682020-04-22 Chronic, eventually fatal, Kawasaki-like disease in an adult with spondylarthropathy responding to IVIG therapy Soltner, Elise Neel, Antoine Tiab, Mourad Varin, Stéphane Cormier, Grégoire Maisonneuve, Hervé Maugars, Yves Tanguy, Gilles Hamidou, Mohamed Berthelot, Jean-Marie Joint Bone Spine Article We report on an unusual case of a 40-year-old Caucasian male displaying severe Kawasaki-like symptoms. The disease lasted for seven years before diffuse coronary aneurysms occurred, leading to the patient's death, despite ongoing treatment by intravenous immunoglobulins (IVIGs). The patient had also been suffering from a disabling inflammation of the spine, which was reported to have started at the onset of the disorder. Whereas neither NSAIDS, nor high doses corticosteroids, or anti-TNF drugs had a clear effect, the clinical features of spinal inflammation were highly sensitive to IVIGs, and were attributed definitively to HLA-B27-negative axial spondylarthropathy after bone scan and magnetic resonance imaging disclosed typical enthesitis of both heels and bilateral sacroiliitis. Société française de rhumatologie. Published by Elsevier Masson SAS 2009-10 2009-05-21 /pmc/articles/PMC7172168/ /pubmed/19464220 http://dx.doi.org/10.1016/j.jbspin.2009.01.006 Text en Copyright © 2009 Société française de rhumatologie. Published by Elsevier Masson SAS All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Soltner, Elise Neel, Antoine Tiab, Mourad Varin, Stéphane Cormier, Grégoire Maisonneuve, Hervé Maugars, Yves Tanguy, Gilles Hamidou, Mohamed Berthelot, Jean-Marie Chronic, eventually fatal, Kawasaki-like disease in an adult with spondylarthropathy responding to IVIG therapy |
title | Chronic, eventually fatal, Kawasaki-like disease in an adult with spondylarthropathy responding to IVIG therapy |
title_full | Chronic, eventually fatal, Kawasaki-like disease in an adult with spondylarthropathy responding to IVIG therapy |
title_fullStr | Chronic, eventually fatal, Kawasaki-like disease in an adult with spondylarthropathy responding to IVIG therapy |
title_full_unstemmed | Chronic, eventually fatal, Kawasaki-like disease in an adult with spondylarthropathy responding to IVIG therapy |
title_short | Chronic, eventually fatal, Kawasaki-like disease in an adult with spondylarthropathy responding to IVIG therapy |
title_sort | chronic, eventually fatal, kawasaki-like disease in an adult with spondylarthropathy responding to ivig therapy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172168/ https://www.ncbi.nlm.nih.gov/pubmed/19464220 http://dx.doi.org/10.1016/j.jbspin.2009.01.006 |
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