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Discovery of a highly divergent hepadnavirus in shrews from China

Limited sampling means that relatively little is known about the diversity and evolutionary history of mammalian members of the Hepadnaviridae (genus Orthohepadnavirus). An important case in point are shrews, the fourth largest group of mammals, but for which there is limited knowledge on the role t...

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Autores principales: Nie, Fang-Yuan, Tian, Jun-Hua, Lin, Xian-Dan, Yu, Bin, Xing, Jian-Guang, Cao, Jian-Hai, Holmes, Edward C., Ma, Runlin Z., Zhang, Yong-Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172195/
https://www.ncbi.nlm.nih.gov/pubmed/30884426
http://dx.doi.org/10.1016/j.virol.2019.03.007
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author Nie, Fang-Yuan
Tian, Jun-Hua
Lin, Xian-Dan
Yu, Bin
Xing, Jian-Guang
Cao, Jian-Hai
Holmes, Edward C.
Ma, Runlin Z.
Zhang, Yong-Zhen
author_facet Nie, Fang-Yuan
Tian, Jun-Hua
Lin, Xian-Dan
Yu, Bin
Xing, Jian-Guang
Cao, Jian-Hai
Holmes, Edward C.
Ma, Runlin Z.
Zhang, Yong-Zhen
author_sort Nie, Fang-Yuan
collection PubMed
description Limited sampling means that relatively little is known about the diversity and evolutionary history of mammalian members of the Hepadnaviridae (genus Orthohepadnavirus). An important case in point are shrews, the fourth largest group of mammals, but for which there is limited knowledge on the role they play in viral evolution and emergence. Here, we report the discovery of a novel shrew hepadnavirus. The newly discovered virus, denoted shrew hepatitis B virus (SHBV), is divergent to be considered a new species of Orthohepadnavirus. Phylogenetic analysis revealed that these viruses were usually most closely related to TBHBV (tent-making bat hepatitis B virus), known to be able to infect human hepatocytes, and had a similar genome structure, although SHBV fell in a more basal position in the surface protein phylogeny. In sum, these data suggest that shrews are natural hosts for hepadnaviruses and may have played an important role in their long-term evolution.
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spelling pubmed-71721952020-04-22 Discovery of a highly divergent hepadnavirus in shrews from China Nie, Fang-Yuan Tian, Jun-Hua Lin, Xian-Dan Yu, Bin Xing, Jian-Guang Cao, Jian-Hai Holmes, Edward C. Ma, Runlin Z. Zhang, Yong-Zhen Virology Article Limited sampling means that relatively little is known about the diversity and evolutionary history of mammalian members of the Hepadnaviridae (genus Orthohepadnavirus). An important case in point are shrews, the fourth largest group of mammals, but for which there is limited knowledge on the role they play in viral evolution and emergence. Here, we report the discovery of a novel shrew hepadnavirus. The newly discovered virus, denoted shrew hepatitis B virus (SHBV), is divergent to be considered a new species of Orthohepadnavirus. Phylogenetic analysis revealed that these viruses were usually most closely related to TBHBV (tent-making bat hepatitis B virus), known to be able to infect human hepatocytes, and had a similar genome structure, although SHBV fell in a more basal position in the surface protein phylogeny. In sum, these data suggest that shrews are natural hosts for hepadnaviruses and may have played an important role in their long-term evolution. Elsevier Inc. 2019-05 2019-03-11 /pmc/articles/PMC7172195/ /pubmed/30884426 http://dx.doi.org/10.1016/j.virol.2019.03.007 Text en © 2019 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Nie, Fang-Yuan
Tian, Jun-Hua
Lin, Xian-Dan
Yu, Bin
Xing, Jian-Guang
Cao, Jian-Hai
Holmes, Edward C.
Ma, Runlin Z.
Zhang, Yong-Zhen
Discovery of a highly divergent hepadnavirus in shrews from China
title Discovery of a highly divergent hepadnavirus in shrews from China
title_full Discovery of a highly divergent hepadnavirus in shrews from China
title_fullStr Discovery of a highly divergent hepadnavirus in shrews from China
title_full_unstemmed Discovery of a highly divergent hepadnavirus in shrews from China
title_short Discovery of a highly divergent hepadnavirus in shrews from China
title_sort discovery of a highly divergent hepadnavirus in shrews from china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172195/
https://www.ncbi.nlm.nih.gov/pubmed/30884426
http://dx.doi.org/10.1016/j.virol.2019.03.007
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