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Cytoplasmic sensing of viral nucleic acids

Viruses are the most abundant pathogens on earth. A fine-tuned framework of intervening pathways is in place in mammalian cells to orchestrate the cellular defence against these pathogens. Key for this system is sensor proteins that recognise specific features associated with nucleic acids of incomi...

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Detalles Bibliográficos
Autores principales: Habjan, Matthias, Pichlmair, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172233/
https://www.ncbi.nlm.nih.gov/pubmed/25668758
http://dx.doi.org/10.1016/j.coviro.2015.01.012
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author Habjan, Matthias
Pichlmair, Andreas
author_facet Habjan, Matthias
Pichlmair, Andreas
author_sort Habjan, Matthias
collection PubMed
description Viruses are the most abundant pathogens on earth. A fine-tuned framework of intervening pathways is in place in mammalian cells to orchestrate the cellular defence against these pathogens. Key for this system is sensor proteins that recognise specific features associated with nucleic acids of incoming viruses. Here we review the current knowledge on cytoplasmic sensors for viral nucleic acids. These sensors induce expression of cytokines, affect cellular functions required for virus replication and directly target viral nucleic acids through degradation or sequestration. Their ability to respond to a given nucleic acid is based on both the differential specificity of the individual proteins and the downstream signalling or adaptor proteins. The cooperation of these multiple proteins and pathways plays a key role in inducing successful immunity against virus infections.
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spelling pubmed-71722332020-04-22 Cytoplasmic sensing of viral nucleic acids Habjan, Matthias Pichlmair, Andreas Curr Opin Virol Article Viruses are the most abundant pathogens on earth. A fine-tuned framework of intervening pathways is in place in mammalian cells to orchestrate the cellular defence against these pathogens. Key for this system is sensor proteins that recognise specific features associated with nucleic acids of incoming viruses. Here we review the current knowledge on cytoplasmic sensors for viral nucleic acids. These sensors induce expression of cytokines, affect cellular functions required for virus replication and directly target viral nucleic acids through degradation or sequestration. Their ability to respond to a given nucleic acid is based on both the differential specificity of the individual proteins and the downstream signalling or adaptor proteins. The cooperation of these multiple proteins and pathways plays a key role in inducing successful immunity against virus infections. Elsevier B.V. 2015-04 2015-02-07 /pmc/articles/PMC7172233/ /pubmed/25668758 http://dx.doi.org/10.1016/j.coviro.2015.01.012 Text en Copyright © 2015 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Habjan, Matthias
Pichlmair, Andreas
Cytoplasmic sensing of viral nucleic acids
title Cytoplasmic sensing of viral nucleic acids
title_full Cytoplasmic sensing of viral nucleic acids
title_fullStr Cytoplasmic sensing of viral nucleic acids
title_full_unstemmed Cytoplasmic sensing of viral nucleic acids
title_short Cytoplasmic sensing of viral nucleic acids
title_sort cytoplasmic sensing of viral nucleic acids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172233/
https://www.ncbi.nlm.nih.gov/pubmed/25668758
http://dx.doi.org/10.1016/j.coviro.2015.01.012
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