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Persistent rhinovirus infection in pediatric hematopoietic stem cell transplant recipients with impaired cellular immunity
BACKGROUND: HRV infections are generally self-limiting in healthy subjects, whereas in immunocompromised hosts HRV infections can lead to severe complications and persistent infections. The persistence of HRV shedding could be due to the inefficient immunological control of a single infectious episo...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172262/ https://www.ncbi.nlm.nih.gov/pubmed/25959156 http://dx.doi.org/10.1016/j.jcv.2015.03.022 |
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author | Piralla, Antonio Zecca, Marco Comoli, Patrizia Girello, Alessia Maccario, Rita Baldanti, Fausto |
author_facet | Piralla, Antonio Zecca, Marco Comoli, Patrizia Girello, Alessia Maccario, Rita Baldanti, Fausto |
author_sort | Piralla, Antonio |
collection | PubMed |
description | BACKGROUND: HRV infections are generally self-limiting in healthy subjects, whereas in immunocompromised hosts HRV infections can lead to severe complications and persistent infections. The persistence of HRV shedding could be due to the inefficient immunological control of a single infectious episode. OBJECTIVES: To investigate the clinical, virologic and immunologic characteristics of pediatric HSCT recipients with HRV-PI infection. STUDY DESIGN: During the period 2006–2012, eight hematopoietic stem cell transplant (HSCT) recipients presented with persistent rhinovirus infection (HRV-PI, ≥30 days). Viral load and T-CD4(+), T-CD8(+), B and NK lymphocyte counts at the onset of infection were compared with those of fourteen HSCT recipients with acute HRV infection (HRV-AI, ≤15 days). RESULTS: The median duration of HRV positivity in patients with HRV-PI was 61 days (range 30–174 days) and phylogenetic analysis showed the persistence of a single HRV type in all patients (100%). In HSCT recipients with HRV-PI, T-CD4(+), T-CD8(+) and NK cell counts at the onset of infection were significantly lower than those observed in recipients with HRV-AI (p < 0.01), while B cell counts were similar in the two groups (p = 0.25). A decrease in HRV load was associated with a significant increase in T-CD4(+), T-CD8(+)and NK lymphocyte counts in HRV-PI patients (p < 0.01). CONCLUSIONS: This study suggests a role for cellular immunity in HRV clearance and highlights the importance of its recovery for the control of HRV infection in HSCT recipients. |
format | Online Article Text |
id | pubmed-7172262 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71722622020-04-22 Persistent rhinovirus infection in pediatric hematopoietic stem cell transplant recipients with impaired cellular immunity Piralla, Antonio Zecca, Marco Comoli, Patrizia Girello, Alessia Maccario, Rita Baldanti, Fausto J Clin Virol Article BACKGROUND: HRV infections are generally self-limiting in healthy subjects, whereas in immunocompromised hosts HRV infections can lead to severe complications and persistent infections. The persistence of HRV shedding could be due to the inefficient immunological control of a single infectious episode. OBJECTIVES: To investigate the clinical, virologic and immunologic characteristics of pediatric HSCT recipients with HRV-PI infection. STUDY DESIGN: During the period 2006–2012, eight hematopoietic stem cell transplant (HSCT) recipients presented with persistent rhinovirus infection (HRV-PI, ≥30 days). Viral load and T-CD4(+), T-CD8(+), B and NK lymphocyte counts at the onset of infection were compared with those of fourteen HSCT recipients with acute HRV infection (HRV-AI, ≤15 days). RESULTS: The median duration of HRV positivity in patients with HRV-PI was 61 days (range 30–174 days) and phylogenetic analysis showed the persistence of a single HRV type in all patients (100%). In HSCT recipients with HRV-PI, T-CD4(+), T-CD8(+) and NK cell counts at the onset of infection were significantly lower than those observed in recipients with HRV-AI (p < 0.01), while B cell counts were similar in the two groups (p = 0.25). A decrease in HRV load was associated with a significant increase in T-CD4(+), T-CD8(+)and NK lymphocyte counts in HRV-PI patients (p < 0.01). CONCLUSIONS: This study suggests a role for cellular immunity in HRV clearance and highlights the importance of its recovery for the control of HRV infection in HSCT recipients. Elsevier B.V. 2015-06 2015-03-31 /pmc/articles/PMC7172262/ /pubmed/25959156 http://dx.doi.org/10.1016/j.jcv.2015.03.022 Text en Copyright © 2015 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Piralla, Antonio Zecca, Marco Comoli, Patrizia Girello, Alessia Maccario, Rita Baldanti, Fausto Persistent rhinovirus infection in pediatric hematopoietic stem cell transplant recipients with impaired cellular immunity |
title | Persistent rhinovirus infection in pediatric hematopoietic stem cell transplant recipients with impaired cellular immunity |
title_full | Persistent rhinovirus infection in pediatric hematopoietic stem cell transplant recipients with impaired cellular immunity |
title_fullStr | Persistent rhinovirus infection in pediatric hematopoietic stem cell transplant recipients with impaired cellular immunity |
title_full_unstemmed | Persistent rhinovirus infection in pediatric hematopoietic stem cell transplant recipients with impaired cellular immunity |
title_short | Persistent rhinovirus infection in pediatric hematopoietic stem cell transplant recipients with impaired cellular immunity |
title_sort | persistent rhinovirus infection in pediatric hematopoietic stem cell transplant recipients with impaired cellular immunity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172262/ https://www.ncbi.nlm.nih.gov/pubmed/25959156 http://dx.doi.org/10.1016/j.jcv.2015.03.022 |
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