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Methyl-RNA: an evolutionary bridge between RNA and DNA?

Given the apparent limitation of double-stranded RNA (dsRNA) genomes to about 30 kb, together with the complexity of DNA synthesis, it appears difficult for a dsRNA genome to encode all the information required before the transition from an RNA to a DNA genome. Ribonucleotide reductase itself, which...

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Detalles Bibliográficos
Autores principales: Poole, Anthony, Penny, David, Sjöberg, Britt-Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd. 2000
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172353/
https://www.ncbi.nlm.nih.gov/pubmed/11137821
http://dx.doi.org/10.1016/S1074-5521(00)00042-9
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author Poole, Anthony
Penny, David
Sjöberg, Britt-Marie
author_facet Poole, Anthony
Penny, David
Sjöberg, Britt-Marie
author_sort Poole, Anthony
collection PubMed
description Given the apparent limitation of double-stranded RNA (dsRNA) genomes to about 30 kb, together with the complexity of DNA synthesis, it appears difficult for a dsRNA genome to encode all the information required before the transition from an RNA to a DNA genome. Ribonucleotide reductase itself, which synthesises deoxyribonucleotides from ribonucleotides, requires complex protein radical chemistry, and RNA world genomes may have reached their limits of coding capacity well before such complex enzymes had evolved. The transition from RNA to DNA thus appears to require intermediate steps, and we suggest that the naturally occurring 2′-O-methylated RNA, with chemical properties intermediate between RNA and DNA, is a suitable candidate.
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spelling pubmed-71723532020-04-22 Methyl-RNA: an evolutionary bridge between RNA and DNA? Poole, Anthony Penny, David Sjöberg, Britt-Marie Chem Biol Article Given the apparent limitation of double-stranded RNA (dsRNA) genomes to about 30 kb, together with the complexity of DNA synthesis, it appears difficult for a dsRNA genome to encode all the information required before the transition from an RNA to a DNA genome. Ribonucleotide reductase itself, which synthesises deoxyribonucleotides from ribonucleotides, requires complex protein radical chemistry, and RNA world genomes may have reached their limits of coding capacity well before such complex enzymes had evolved. The transition from RNA to DNA thus appears to require intermediate steps, and we suggest that the naturally occurring 2′-O-methylated RNA, with chemical properties intermediate between RNA and DNA, is a suitable candidate. Elsevier Science Ltd. 2000-12 2004-06-17 /pmc/articles/PMC7172353/ /pubmed/11137821 http://dx.doi.org/10.1016/S1074-5521(00)00042-9 Text en Copyright © 2000 Elsevier Science Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Poole, Anthony
Penny, David
Sjöberg, Britt-Marie
Methyl-RNA: an evolutionary bridge between RNA and DNA?
title Methyl-RNA: an evolutionary bridge between RNA and DNA?
title_full Methyl-RNA: an evolutionary bridge between RNA and DNA?
title_fullStr Methyl-RNA: an evolutionary bridge between RNA and DNA?
title_full_unstemmed Methyl-RNA: an evolutionary bridge between RNA and DNA?
title_short Methyl-RNA: an evolutionary bridge between RNA and DNA?
title_sort methyl-rna: an evolutionary bridge between rna and dna?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172353/
https://www.ncbi.nlm.nih.gov/pubmed/11137821
http://dx.doi.org/10.1016/S1074-5521(00)00042-9
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