Whither vaccines?

Currently used vaccines have had major effects on eliminating common infections, largely by duplicating the immune responses induced by natural infections. Now vaccinology faces more complex problems, such as waning antibody, immunosenescence, evasion of immunity by the pathogen, deviation of immuni...

Descripción completa

Detalles Bibliográficos
Autores principales: Rodrigues, Charlene M.C., Pinto, Marta V., Sadarangani, Manish, Plotkin, Stanley A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Infection Association. Published by Elsevier Ltd. 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172359/
https://www.ncbi.nlm.nih.gov/pubmed/28646957
http://dx.doi.org/10.1016/S0163-4453(17)30184-6
_version_ 1783524242436915200
author Rodrigues, Charlene M.C.
Pinto, Marta V.
Sadarangani, Manish
Plotkin, Stanley A.
author_facet Rodrigues, Charlene M.C.
Pinto, Marta V.
Sadarangani, Manish
Plotkin, Stanley A.
author_sort Rodrigues, Charlene M.C.
collection PubMed
description Currently used vaccines have had major effects on eliminating common infections, largely by duplicating the immune responses induced by natural infections. Now vaccinology faces more complex problems, such as waning antibody, immunosenescence, evasion of immunity by the pathogen, deviation of immunity by the microbiome, induction of inhibitory responses, and complexity of the antigens required for protection. Fortunately, vaccine development is now incorporating knowledge from immunology, structural biology, systems biology and synthetic chemistry to meet these challenges. In addition, international organisations are developing new funding and licensing pathways for vaccines aimed at pathogens with epidemic potential that emerge from tropical areas.
format Online
Article
Text
id pubmed-7172359
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher The British Infection Association. Published by Elsevier Ltd.
record_format MEDLINE/PubMed
spelling pubmed-71723592020-04-22 Whither vaccines? Rodrigues, Charlene M.C. Pinto, Marta V. Sadarangani, Manish Plotkin, Stanley A. J Infect Article Currently used vaccines have had major effects on eliminating common infections, largely by duplicating the immune responses induced by natural infections. Now vaccinology faces more complex problems, such as waning antibody, immunosenescence, evasion of immunity by the pathogen, deviation of immunity by the microbiome, induction of inhibitory responses, and complexity of the antigens required for protection. Fortunately, vaccine development is now incorporating knowledge from immunology, structural biology, systems biology and synthetic chemistry to meet these challenges. In addition, international organisations are developing new funding and licensing pathways for vaccines aimed at pathogens with epidemic potential that emerge from tropical areas. The British Infection Association. Published by Elsevier Ltd. 2017-06 2017-06-21 /pmc/articles/PMC7172359/ /pubmed/28646957 http://dx.doi.org/10.1016/S0163-4453(17)30184-6 Text en © 2017 The British Infection Association Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Rodrigues, Charlene M.C.
Pinto, Marta V.
Sadarangani, Manish
Plotkin, Stanley A.
Whither vaccines?
title Whither vaccines?
title_full Whither vaccines?
title_fullStr Whither vaccines?
title_full_unstemmed Whither vaccines?
title_short Whither vaccines?
title_sort whither vaccines?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172359/
https://www.ncbi.nlm.nih.gov/pubmed/28646957
http://dx.doi.org/10.1016/S0163-4453(17)30184-6
work_keys_str_mv AT rodriguescharlenemc whithervaccines
AT pintomartav whithervaccines
AT sadaranganimanish whithervaccines
AT plotkinstanleya whithervaccines

Ejemplares similares