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The cyclophilin-inhibitor alisporivir stimulates antigen presentation thereby promoting antigen-specific CD8(+) T cell activation

BACKGROUND & AIMS: Cyclophilin-inhibitors have potent antiviral activity against Hepatitis C virus (HCV) and are promising candidates for broad-spectrum antiviral therapy. Cyclosporine A (CsA) acts immunosuppressive by blocking T cell activation and antigen presentation. Alisporivir, a non-immun...

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Detalles Bibliográficos
Autores principales:	Esser-Nobis, Katharina, Schmidt, Julia, Nitschke, Katja, Neumann-Haefelin, Christoph, Thimme, Robert, Lohmann, Volker
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	European Association for the Study of the Liver. Published by Elsevier B.V. 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172366/ https://www.ncbi.nlm.nih.gov/pubmed/26921685 http://dx.doi.org/10.1016/j.jhep.2016.02.027

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