Alphaviruses — vectors for the expression of heterologous genes

DNA viruses and retroviruses are well established as vectors for the expression of heterologous genes, but there is increasing interest in the possibilities of using RNA viruses, which do not replicate through a DNA intermediate, for this purpose. This article summarizes some of the general properti...

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Detalles Bibliográficos
Autor principal: Schlesinger, Sondra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 1993
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172487/
https://www.ncbi.nlm.nih.gov/pubmed/7764041
http://dx.doi.org/10.1016/0167-7799(93)90070-P
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author Schlesinger, Sondra
author_facet Schlesinger, Sondra
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description DNA viruses and retroviruses are well established as vectors for the expression of heterologous genes, but there is increasing interest in the possibilities of using RNA viruses, which do not replicate through a DNA intermediate, for this purpose. This article summarizes some of the general properties of RNA viruses and concentrates on one class of RNA viruses — the alphaviruses — and their potential as expression vectors.
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spelling pubmed-71724872020-04-22 Alphaviruses — vectors for the expression of heterologous genes Schlesinger, Sondra Trends Biotechnol Article DNA viruses and retroviruses are well established as vectors for the expression of heterologous genes, but there is increasing interest in the possibilities of using RNA viruses, which do not replicate through a DNA intermediate, for this purpose. This article summarizes some of the general properties of RNA viruses and concentrates on one class of RNA viruses — the alphaviruses — and their potential as expression vectors. Published by Elsevier Ltd. 1993-01 2004-08-26 /pmc/articles/PMC7172487/ /pubmed/7764041 http://dx.doi.org/10.1016/0167-7799(93)90070-P Text en Copyright © 1993 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Schlesinger, Sondra
Alphaviruses — vectors for the expression of heterologous genes
title Alphaviruses — vectors for the expression of heterologous genes
title_full Alphaviruses — vectors for the expression of heterologous genes
title_fullStr Alphaviruses — vectors for the expression of heterologous genes
title_full_unstemmed Alphaviruses — vectors for the expression of heterologous genes
title_short Alphaviruses — vectors for the expression of heterologous genes
title_sort alphaviruses — vectors for the expression of heterologous genes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172487/
https://www.ncbi.nlm.nih.gov/pubmed/7764041
http://dx.doi.org/10.1016/0167-7799(93)90070-P
work_keys_str_mv AT schlesingersondra alphavirusesvectorsfortheexpressionofheterologousgenes

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