Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents

The tylophorine analog rac-cryptopleurine exhibited potent anti-hepatitis C virus (HCV) activity through allosteric regulation of ATPase activity of heat shock cognate protein 70 (Hsc70). We evaluated the impact of modifications on the E-ring of rac-cryptopleurine to the inhibitory activity against...

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Detalles Bibliográficos
Autores principales: Wang, Ying, Chen, Shao-Ru, Yang, Xiaoming, Lee, Kuo-Hsiung, Cheng, Yung-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172637/
https://www.ncbi.nlm.nih.gov/pubmed/29317151
http://dx.doi.org/10.1016/j.bmc.2017.12.027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172637/
https://www.ncbi.nlm.nih.gov/pubmed/29317151
http://dx.doi.org/10.1016/j.bmc.2017.12.027

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