Cyclosporin derivatives inhibit hepatitis B virus entry without interfering with NTCP transporter activity

BACKGROUND & AIMS: The sodium taurocholate co-transporting polypeptide (NTCP) is the main target of most hepatitis B virus (HBV) specific entry inhibitors. Unfortunately, these agents also block NTCP transport of bile acids into hepatocytes, and thus have the potential to cause adverse effects....

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Detalles Bibliográficos
Autores principales: Shimura, Satomi, Watashi, Koichi, Fukano, Kento, Peel, Michael, Sluder, Ann, Kawai, Fumihiro, Iwamoto, Masashi, Tsukuda, Senko, Takeuchi, Junko S., Miyake, Takeshi, Sugiyama, Masaya, Ogasawara, Yuki, Park, Sam-Yong, Tanaka, Yasuhito, Kusuhara, Hiroyuki, Mizokami, Masashi, Sureau, Camille, Wakita, Takaji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Association for the Study of the Liver. Published by Elsevier B.V. 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172969/
https://www.ncbi.nlm.nih.gov/pubmed/27890789
http://dx.doi.org/10.1016/j.jhep.2016.11.009

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