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The α(1,2)‐mannosidase I inhibitor 1‐deoxymannojirimycin potentiates the antiviral activity of carbohydrate‐binding agents against wild‐type and mutant HIV‐1 strains containing glycan deletions in gp120
Exposure of carbohydrate‐binding agents (CBAs) (i.e. the mannose‐specific plant lectins Hippeastrum hybrid agglutinin and Galanthus nivalis agglutinin) to HIV‐1 progressively select for mutant HIV‐1 strains that contain N‐glycan deletions in their envelope gp120. This results in resistance of the mu...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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John Wiley and Sons Inc.
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173009/ https://www.ncbi.nlm.nih.gov/pubmed/17475258 http://dx.doi.org/10.1016/j.febslet.2007.04.039 |