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Identification of novel and diverse rotaviruses in rodents and insectivores, and evidence of cross-species transmission into humans

Rotaviruses are an important cause of severe diarrheal illness in children globally. We characterized rotaviruses sampled in humans, insectivores (shrews) and rodents from urban and rural regions of Zhejiang province, China. Phylogenetic analyses revealed seven genotypic constellations of human rota...

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Detalles Bibliográficos
Autores principales: Li, Kun, Lin, Xian-Dan, Huang, Kai-Yu, Zhang, Bing, Shi, Mang, Guo, Wen-Ping, Wang, Miao-Ruo, Wang, Wen, Xing, Jian-Guang, Li, Ming-Hui, Hong, Wang-Sheng, Holmes, Edward C., Zhang, Yong-Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173014/
https://www.ncbi.nlm.nih.gov/pubmed/27115729
http://dx.doi.org/10.1016/j.virol.2016.04.017
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author Li, Kun
Lin, Xian-Dan
Huang, Kai-Yu
Zhang, Bing
Shi, Mang
Guo, Wen-Ping
Wang, Miao-Ruo
Wang, Wen
Xing, Jian-Guang
Li, Ming-Hui
Hong, Wang-Sheng
Holmes, Edward C.
Zhang, Yong-Zhen
author_facet Li, Kun
Lin, Xian-Dan
Huang, Kai-Yu
Zhang, Bing
Shi, Mang
Guo, Wen-Ping
Wang, Miao-Ruo
Wang, Wen
Xing, Jian-Guang
Li, Ming-Hui
Hong, Wang-Sheng
Holmes, Edward C.
Zhang, Yong-Zhen
author_sort Li, Kun
collection PubMed
description Rotaviruses are an important cause of severe diarrheal illness in children globally. We characterized rotaviruses sampled in humans, insectivores (shrews) and rodents from urban and rural regions of Zhejiang province, China. Phylogenetic analyses revealed seven genotypic constellations of human rotaviruses with six different combinations of G and P genotypes – G3P[8] (50.06%), G9P[8] (36.16%), G1P[8] (8.92%), G2P[4] (4.63%), G3P[3] (0.12%), and G3P[9] (0.12%). In rodents and shrews sampled from the same locality we identified a novel genotype constellation (G32-P[46]-I24-R18-C17-M17-A28-N17-T19-E24-H19), a novel P genotype (P[45]), and two different AU-1-like rotaviruses associated with a G3P[3] genotype combination. Of particular note was a novel rotavirus from a human patient that was closely related to viruses sampled from rodents in the same region, indicative of a local species jump. In sum, these data are suggestive of the cross-species transmission of rodent rotaviruses into humans and for reassortment among human and animal rotaviruses.
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spelling pubmed-71730142020-04-22 Identification of novel and diverse rotaviruses in rodents and insectivores, and evidence of cross-species transmission into humans Li, Kun Lin, Xian-Dan Huang, Kai-Yu Zhang, Bing Shi, Mang Guo, Wen-Ping Wang, Miao-Ruo Wang, Wen Xing, Jian-Guang Li, Ming-Hui Hong, Wang-Sheng Holmes, Edward C. Zhang, Yong-Zhen Virology Article Rotaviruses are an important cause of severe diarrheal illness in children globally. We characterized rotaviruses sampled in humans, insectivores (shrews) and rodents from urban and rural regions of Zhejiang province, China. Phylogenetic analyses revealed seven genotypic constellations of human rotaviruses with six different combinations of G and P genotypes – G3P[8] (50.06%), G9P[8] (36.16%), G1P[8] (8.92%), G2P[4] (4.63%), G3P[3] (0.12%), and G3P[9] (0.12%). In rodents and shrews sampled from the same locality we identified a novel genotype constellation (G32-P[46]-I24-R18-C17-M17-A28-N17-T19-E24-H19), a novel P genotype (P[45]), and two different AU-1-like rotaviruses associated with a G3P[3] genotype combination. Of particular note was a novel rotavirus from a human patient that was closely related to viruses sampled from rodents in the same region, indicative of a local species jump. In sum, these data are suggestive of the cross-species transmission of rodent rotaviruses into humans and for reassortment among human and animal rotaviruses. Elsevier Inc. 2016-07 2016-04-26 /pmc/articles/PMC7173014/ /pubmed/27115729 http://dx.doi.org/10.1016/j.virol.2016.04.017 Text en © 2016 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Li, Kun
Lin, Xian-Dan
Huang, Kai-Yu
Zhang, Bing
Shi, Mang
Guo, Wen-Ping
Wang, Miao-Ruo
Wang, Wen
Xing, Jian-Guang
Li, Ming-Hui
Hong, Wang-Sheng
Holmes, Edward C.
Zhang, Yong-Zhen
Identification of novel and diverse rotaviruses in rodents and insectivores, and evidence of cross-species transmission into humans
title Identification of novel and diverse rotaviruses in rodents and insectivores, and evidence of cross-species transmission into humans
title_full Identification of novel and diverse rotaviruses in rodents and insectivores, and evidence of cross-species transmission into humans
title_fullStr Identification of novel and diverse rotaviruses in rodents and insectivores, and evidence of cross-species transmission into humans
title_full_unstemmed Identification of novel and diverse rotaviruses in rodents and insectivores, and evidence of cross-species transmission into humans
title_short Identification of novel and diverse rotaviruses in rodents and insectivores, and evidence of cross-species transmission into humans
title_sort identification of novel and diverse rotaviruses in rodents and insectivores, and evidence of cross-species transmission into humans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173014/
https://www.ncbi.nlm.nih.gov/pubmed/27115729
http://dx.doi.org/10.1016/j.virol.2016.04.017
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