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Complex Carbohydrates in Drug Development
Recent advances in carbohydrate chemistry and biochemistry afford the opportunity to develop bioactive complex carbohydrates, per se, as drugs or as lead compounds in drug development. Complex carbohydrates are unique among biopolymers in their inherent potential to generate diverse molecular struct...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Academic Press Inc. Published by Elsevier Inc.
1992
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173135/ https://www.ncbi.nlm.nih.gov/pubmed/1540539 http://dx.doi.org/10.1016/S1054-3589(08)60962-X |
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author | Schnaar, Ronald L. |
author_facet | Schnaar, Ronald L. |
author_sort | Schnaar, Ronald L. |
collection | PubMed |
description | Recent advances in carbohydrate chemistry and biochemistry afford the opportunity to develop bioactive complex carbohydrates, per se, as drugs or as lead compounds in drug development. Complex carbohydrates are unique among biopolymers in their inherent potential to generate diverse molecular structures. While proteins vary only in the linear sequence of their monomer constituents, individual monosaccharides can combine at any of several sites on each carbohydrate ring, in linear or branched arrays, and with varied stereochemistry at each linkage bond. This chapter addresses some salient features of mammalian glycoconjugate structure and biosynthesis, and presents examples of the biological activities of complex carbohydrates. The chapter presents selected examples that will provide an accurate introduction to their pharmacological potential. In addition to their independent functions, oligosaccharides can modify the activities of proteins to which they are covalently attached. Many glycoprotein enzymes and hormones require glycosylation for expression and function. The chapter discusses the ancillary role of carbohydrates that is of great importance to the use of engineered glycoproteins as pharmaceuticals. |
format | Online Article Text |
id | pubmed-7173135 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1992 |
publisher | Academic Press Inc. Published by Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71731352020-04-22 Complex Carbohydrates in Drug Development Schnaar, Ronald L. Adv Pharmacol Article Recent advances in carbohydrate chemistry and biochemistry afford the opportunity to develop bioactive complex carbohydrates, per se, as drugs or as lead compounds in drug development. Complex carbohydrates are unique among biopolymers in their inherent potential to generate diverse molecular structures. While proteins vary only in the linear sequence of their monomer constituents, individual monosaccharides can combine at any of several sites on each carbohydrate ring, in linear or branched arrays, and with varied stereochemistry at each linkage bond. This chapter addresses some salient features of mammalian glycoconjugate structure and biosynthesis, and presents examples of the biological activities of complex carbohydrates. The chapter presents selected examples that will provide an accurate introduction to their pharmacological potential. In addition to their independent functions, oligosaccharides can modify the activities of proteins to which they are covalently attached. Many glycoprotein enzymes and hormones require glycosylation for expression and function. The chapter discusses the ancillary role of carbohydrates that is of great importance to the use of engineered glycoproteins as pharmaceuticals. Academic Press Inc. Published by Elsevier Inc. 1992 2008-06-18 /pmc/articles/PMC7173135/ /pubmed/1540539 http://dx.doi.org/10.1016/S1054-3589(08)60962-X Text en © 1992 Academic Press Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Schnaar, Ronald L. Complex Carbohydrates in Drug Development |
title | Complex Carbohydrates in Drug Development |
title_full | Complex Carbohydrates in Drug Development |
title_fullStr | Complex Carbohydrates in Drug Development |
title_full_unstemmed | Complex Carbohydrates in Drug Development |
title_short | Complex Carbohydrates in Drug Development |
title_sort | complex carbohydrates in drug development |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173135/ https://www.ncbi.nlm.nih.gov/pubmed/1540539 http://dx.doi.org/10.1016/S1054-3589(08)60962-X |
work_keys_str_mv | AT schnaarronaldl complexcarbohydratesindrugdevelopment |