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Phylodynamic analysis and molecular diversity of the avian infectious bronchitis virus of chickens in Brazil
Avian infectious bronchitis virus (IBV) is the etiological agent of a highly contagious disease, which results in severe economic losses to the poultry industry. The spike protein (S1 subunit) is responsible for the molecular diversity of the virus and many sero/genotypes are described around the wo...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173207/ https://www.ncbi.nlm.nih.gov/pubmed/29574164 http://dx.doi.org/10.1016/j.meegid.2018.03.014 |
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author | Fraga, Aline Padilha de Gräf, Tiago Pereira, Cleiton Schneider Ikuta, Nilo Fonseca, André Salvador Kazantzi Lunge, Vagner Ricardo |
author_facet | Fraga, Aline Padilha de Gräf, Tiago Pereira, Cleiton Schneider Ikuta, Nilo Fonseca, André Salvador Kazantzi Lunge, Vagner Ricardo |
author_sort | Fraga, Aline Padilha de |
collection | PubMed |
description | Avian infectious bronchitis virus (IBV) is the etiological agent of a highly contagious disease, which results in severe economic losses to the poultry industry. The spike protein (S1 subunit) is responsible for the molecular diversity of the virus and many sero/genotypes are described around the world. Recently a new standardized classification of the IBV molecular diversity was conducted, based on phylogenetic analysis of the S1 gene sequences sampled worldwide. Brazil is one of the biggest poultry producers in the world and the present study aimed to review the molecular diversity and reconstruct the evolutionary history of IBV in the country. All IBV S1 gene sequences, with local and year of collection information available on GenBank, were retrieved. Phylogenetic analyses were carried out based on a maximum likelihood method for the classification of genotypes occurring in Brazil, according to the new classification. Bayesian phylogenetic analyses were performed with the Brazilian clade and related international sequences to determine the evolutionary history of IBV in Brazil. A total of 143 Brazilian sequences were classified as GI-11 and 46 as GI-1 (Mass). Within the GI-11 clade, we have identified a potential recombinant strain circulating in Brazil. Phylodynamic analysis demonstrated that IBV GI-11 lineage was introduced in Brazil in the 1950s (1951, 1917–1975 95% HPD) and population dynamics was mostly constant throughout the time. Despite the national vaccination protocols, our results show the widespread dissemination and maintenance of the IBV GI-11 lineage in Brazil and highlight the importance of continuous surveillance to evaluate the impact of currently used vaccine strains on the observed viral diversity of the country. |
format | Online Article Text |
id | pubmed-7173207 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71732072020-04-22 Phylodynamic analysis and molecular diversity of the avian infectious bronchitis virus of chickens in Brazil Fraga, Aline Padilha de Gräf, Tiago Pereira, Cleiton Schneider Ikuta, Nilo Fonseca, André Salvador Kazantzi Lunge, Vagner Ricardo Infect Genet Evol Research Paper Avian infectious bronchitis virus (IBV) is the etiological agent of a highly contagious disease, which results in severe economic losses to the poultry industry. The spike protein (S1 subunit) is responsible for the molecular diversity of the virus and many sero/genotypes are described around the world. Recently a new standardized classification of the IBV molecular diversity was conducted, based on phylogenetic analysis of the S1 gene sequences sampled worldwide. Brazil is one of the biggest poultry producers in the world and the present study aimed to review the molecular diversity and reconstruct the evolutionary history of IBV in the country. All IBV S1 gene sequences, with local and year of collection information available on GenBank, were retrieved. Phylogenetic analyses were carried out based on a maximum likelihood method for the classification of genotypes occurring in Brazil, according to the new classification. Bayesian phylogenetic analyses were performed with the Brazilian clade and related international sequences to determine the evolutionary history of IBV in Brazil. A total of 143 Brazilian sequences were classified as GI-11 and 46 as GI-1 (Mass). Within the GI-11 clade, we have identified a potential recombinant strain circulating in Brazil. Phylodynamic analysis demonstrated that IBV GI-11 lineage was introduced in Brazil in the 1950s (1951, 1917–1975 95% HPD) and population dynamics was mostly constant throughout the time. Despite the national vaccination protocols, our results show the widespread dissemination and maintenance of the IBV GI-11 lineage in Brazil and highlight the importance of continuous surveillance to evaluate the impact of currently used vaccine strains on the observed viral diversity of the country. Elsevier B.V. 2018-07 2018-03-21 /pmc/articles/PMC7173207/ /pubmed/29574164 http://dx.doi.org/10.1016/j.meegid.2018.03.014 Text en © 2018 Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Research Paper Fraga, Aline Padilha de Gräf, Tiago Pereira, Cleiton Schneider Ikuta, Nilo Fonseca, André Salvador Kazantzi Lunge, Vagner Ricardo Phylodynamic analysis and molecular diversity of the avian infectious bronchitis virus of chickens in Brazil |
title | Phylodynamic analysis and molecular diversity of the avian infectious bronchitis virus of chickens in Brazil |
title_full | Phylodynamic analysis and molecular diversity of the avian infectious bronchitis virus of chickens in Brazil |
title_fullStr | Phylodynamic analysis and molecular diversity of the avian infectious bronchitis virus of chickens in Brazil |
title_full_unstemmed | Phylodynamic analysis and molecular diversity of the avian infectious bronchitis virus of chickens in Brazil |
title_short | Phylodynamic analysis and molecular diversity of the avian infectious bronchitis virus of chickens in Brazil |
title_sort | phylodynamic analysis and molecular diversity of the avian infectious bronchitis virus of chickens in brazil |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173207/ https://www.ncbi.nlm.nih.gov/pubmed/29574164 http://dx.doi.org/10.1016/j.meegid.2018.03.014 |
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