Inactivation of viral antigens for vaccine preparation with particular reference to the application of binary ethylenimine

Viral antigens for human and veterinary vaccines are still inactivated with formaldehyde. This is not an ideal inactivant and the problems of formaldehyde inactivation of vaccines are discussed. Vaccines inactivated with aziridines are superior in safety and antigenicity. Aziridines inactivate virus...

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Autor principal: Bahnemann, Hans G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 1990
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173316/
https://www.ncbi.nlm.nih.gov/pubmed/2204242
http://dx.doi.org/10.1016/0264-410X(90)90083-X
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author Bahnemann, Hans G.
author_facet Bahnemann, Hans G.
author_sort Bahnemann, Hans G.
collection PubMed
description Viral antigens for human and veterinary vaccines are still inactivated with formaldehyde. This is not an ideal inactivant and the problems of formaldehyde inactivation of vaccines are discussed. Vaccines inactivated with aziridines are superior in safety and antigenicity. Aziridines inactivate viruses in a first-order reaction and the inactivation rate and endpoint can be determined. The preparation and application of the aziridine compound binary ethylenimine (BEI) and the necessary conditions for and controls of the inactivation process are described and discussed. A computer program has been written for assistance in the use of BEI for controlled inactivation of viral antigens.
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spelling pubmed-71733162020-04-22 Inactivation of viral antigens for vaccine preparation with particular reference to the application of binary ethylenimine Bahnemann, Hans G. Vaccine Article Viral antigens for human and veterinary vaccines are still inactivated with formaldehyde. This is not an ideal inactivant and the problems of formaldehyde inactivation of vaccines are discussed. Vaccines inactivated with aziridines are superior in safety and antigenicity. Aziridines inactivate viruses in a first-order reaction and the inactivation rate and endpoint can be determined. The preparation and application of the aziridine compound binary ethylenimine (BEI) and the necessary conditions for and controls of the inactivation process are described and discussed. A computer program has been written for assistance in the use of BEI for controlled inactivation of viral antigens. Published by Elsevier Ltd. 1990-08 2002-11-12 /pmc/articles/PMC7173316/ /pubmed/2204242 http://dx.doi.org/10.1016/0264-410X(90)90083-X Text en Copyright © 1990 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Bahnemann, Hans G.
Inactivation of viral antigens for vaccine preparation with particular reference to the application of binary ethylenimine
title Inactivation of viral antigens for vaccine preparation with particular reference to the application of binary ethylenimine
title_full Inactivation of viral antigens for vaccine preparation with particular reference to the application of binary ethylenimine
title_fullStr Inactivation of viral antigens for vaccine preparation with particular reference to the application of binary ethylenimine
title_full_unstemmed Inactivation of viral antigens for vaccine preparation with particular reference to the application of binary ethylenimine
title_short Inactivation of viral antigens for vaccine preparation with particular reference to the application of binary ethylenimine
title_sort inactivation of viral antigens for vaccine preparation with particular reference to the application of binary ethylenimine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173316/
https://www.ncbi.nlm.nih.gov/pubmed/2204242
http://dx.doi.org/10.1016/0264-410X(90)90083-X
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