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Rhinoviruses significantly affect day-to-day respiratory symptoms of children with asthma
BACKGROUND: Viruses are frequently associated with acute exacerbations of asthma, but the extent to which they contribute to the level of day-to-day symptom control is less clear. OBJECTIVE: We sought to explore the relationship between viral infections, host and environmental factors, and respirato...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173323/ https://www.ncbi.nlm.nih.gov/pubmed/25476729 http://dx.doi.org/10.1016/j.jaci.2014.10.020 |
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author | Tovey, Euan R. Stelzer-Braid, Sacha Toelle, Brett G. Oliver, Brian G. Reddel, Helen K. Willenborg, Christiana M. Belessis, Yvonne Garden, Frances L. Jaffe, Adam Strachan, Roxanne Eyles, Darryl Rawlinson, William D. Marks, Guy B. |
author_facet | Tovey, Euan R. Stelzer-Braid, Sacha Toelle, Brett G. Oliver, Brian G. Reddel, Helen K. Willenborg, Christiana M. Belessis, Yvonne Garden, Frances L. Jaffe, Adam Strachan, Roxanne Eyles, Darryl Rawlinson, William D. Marks, Guy B. |
author_sort | Tovey, Euan R. |
collection | PubMed |
description | BACKGROUND: Viruses are frequently associated with acute exacerbations of asthma, but the extent to which they contribute to the level of day-to-day symptom control is less clear. OBJECTIVE: We sought to explore the relationship between viral infections, host and environmental factors, and respiratory symptoms in children. METHODS: Sixty-seven asthmatic children collected samples twice weekly for an average of 10 weeks. These included nasal wash fluid and exhaled breath for PCR-based detection of viral RNA, lung function measurements, and records of medication use and asthma and respiratory symptoms in the previous 3 days. Atopy, mite allergen exposure, and vitamin D levels were also measured. Mixed-model regression analyses were performed. RESULTS: Human rhinoviruses (hRVs) were detected in 25.5% of 1232 nasal samples and 11.5% of breath samples. Non-hRV viruses were detected in less than 3% of samples. hRV in nasal samples was associated with asthma symptoms (cough and phlegm: odds ratio = 2.0; 95% CI = 1.4-2.86, P = .0001; wheeze and chest tightness: odds ratio = 2.34, 95% CI = 1.55-3.52, P < .0001) and with cold symptoms, as reported concurrently with sampling and 3 to 4 days later. No differences were found between the 3 hRV genotypes (hRV-A, hRV-B, and hRV-C) in symptom risk. A history of inhaled corticosteroid use, but not atopic status, mite allergen exposure, or vitamin D levels, modified the association between viruses and asthma symptoms. CONCLUSION: The detection of nasal hRV was associated with a significantly increased risk of day-to-day asthma symptoms in children. Host, virus genotype, and environmental factors each had only a small or no effect on the relationship of viral infections to asthma symptoms. |
format | Online Article Text |
id | pubmed-7173323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71733232020-04-22 Rhinoviruses significantly affect day-to-day respiratory symptoms of children with asthma Tovey, Euan R. Stelzer-Braid, Sacha Toelle, Brett G. Oliver, Brian G. Reddel, Helen K. Willenborg, Christiana M. Belessis, Yvonne Garden, Frances L. Jaffe, Adam Strachan, Roxanne Eyles, Darryl Rawlinson, William D. Marks, Guy B. J Allergy Clin Immunol Article BACKGROUND: Viruses are frequently associated with acute exacerbations of asthma, but the extent to which they contribute to the level of day-to-day symptom control is less clear. OBJECTIVE: We sought to explore the relationship between viral infections, host and environmental factors, and respiratory symptoms in children. METHODS: Sixty-seven asthmatic children collected samples twice weekly for an average of 10 weeks. These included nasal wash fluid and exhaled breath for PCR-based detection of viral RNA, lung function measurements, and records of medication use and asthma and respiratory symptoms in the previous 3 days. Atopy, mite allergen exposure, and vitamin D levels were also measured. Mixed-model regression analyses were performed. RESULTS: Human rhinoviruses (hRVs) were detected in 25.5% of 1232 nasal samples and 11.5% of breath samples. Non-hRV viruses were detected in less than 3% of samples. hRV in nasal samples was associated with asthma symptoms (cough and phlegm: odds ratio = 2.0; 95% CI = 1.4-2.86, P = .0001; wheeze and chest tightness: odds ratio = 2.34, 95% CI = 1.55-3.52, P < .0001) and with cold symptoms, as reported concurrently with sampling and 3 to 4 days later. No differences were found between the 3 hRV genotypes (hRV-A, hRV-B, and hRV-C) in symptom risk. A history of inhaled corticosteroid use, but not atopic status, mite allergen exposure, or vitamin D levels, modified the association between viruses and asthma symptoms. CONCLUSION: The detection of nasal hRV was associated with a significantly increased risk of day-to-day asthma symptoms in children. Host, virus genotype, and environmental factors each had only a small or no effect on the relationship of viral infections to asthma symptoms. American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. 2015-03 2014-12-02 /pmc/articles/PMC7173323/ /pubmed/25476729 http://dx.doi.org/10.1016/j.jaci.2014.10.020 Text en Copyright © 2014 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Tovey, Euan R. Stelzer-Braid, Sacha Toelle, Brett G. Oliver, Brian G. Reddel, Helen K. Willenborg, Christiana M. Belessis, Yvonne Garden, Frances L. Jaffe, Adam Strachan, Roxanne Eyles, Darryl Rawlinson, William D. Marks, Guy B. Rhinoviruses significantly affect day-to-day respiratory symptoms of children with asthma |
title | Rhinoviruses significantly affect day-to-day respiratory symptoms of children with asthma |
title_full | Rhinoviruses significantly affect day-to-day respiratory symptoms of children with asthma |
title_fullStr | Rhinoviruses significantly affect day-to-day respiratory symptoms of children with asthma |
title_full_unstemmed | Rhinoviruses significantly affect day-to-day respiratory symptoms of children with asthma |
title_short | Rhinoviruses significantly affect day-to-day respiratory symptoms of children with asthma |
title_sort | rhinoviruses significantly affect day-to-day respiratory symptoms of children with asthma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173323/ https://www.ncbi.nlm.nih.gov/pubmed/25476729 http://dx.doi.org/10.1016/j.jaci.2014.10.020 |
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