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Respiratory infections in Eñepa Amerindians are related to malnutrition and Streptococcus pneumoniae carriage

OBJECTIVES: High acute respiratory tract infection (ARTI) rates are observed in indigenous populations. We assessed the role of viral infections and nasopharyngeal bacterial carriage in ARTIs in Eñepa Amerindians from Venezuela. METHODS: In 40 children aged 0–10 years with ARTIs, healthy nearest-age...

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Autores principales: Verhagen, Lilly M., Gómez-Castellano, Keyla, Snelders, Eveline, Rivera-Olivero, Ismar, Pocaterra, Leonor, Melchers, Willem J.G., de Waard, Jacobus H., Hermans, Peter W.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Infection Association. Published by Elsevier Ltd. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173337/
https://www.ncbi.nlm.nih.gov/pubmed/23796866
http://dx.doi.org/10.1016/j.jinf.2013.06.010
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author Verhagen, Lilly M.
Gómez-Castellano, Keyla
Snelders, Eveline
Rivera-Olivero, Ismar
Pocaterra, Leonor
Melchers, Willem J.G.
de Waard, Jacobus H.
Hermans, Peter W.M.
author_facet Verhagen, Lilly M.
Gómez-Castellano, Keyla
Snelders, Eveline
Rivera-Olivero, Ismar
Pocaterra, Leonor
Melchers, Willem J.G.
de Waard, Jacobus H.
Hermans, Peter W.M.
author_sort Verhagen, Lilly M.
collection PubMed
description OBJECTIVES: High acute respiratory tract infection (ARTI) rates are observed in indigenous populations. We assessed the role of viral infections and nasopharyngeal bacterial carriage in ARTIs in Eñepa Amerindians from Venezuela. METHODS: In 40 children aged 0–10 years with ARTIs, healthy nearest-age sibling controls and their mothers the presence of Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Moraxella catarrhalis, Mycoplasma pneumoniae, Chlamydophila pneumoniae/psittachi and 15 respiratory viruses was investigated. RESULTS: S. pneumoniae was the most frequently detected pathogen, with carriage rates of 75% and 38% in children and mothers respectively. In children, S. pneumoniae carriage was associated with ARTI risk in multivariate analysis (OR 14.1, 95% CI 1.4–137.7). Viral infections were not associated with ARTI risk. S. pneumoniae carriage was common in children of all ages while viral co-infections were more frequently present in children under 4 years compared to older children (46% vs. 17%, p < 0.01). An increase of one unit height-for-age Z score (i.e. improved chronic nutritional status) was associated with decreased odds of S. pneumoniae colonization in multivariate analysis (OR 0.66, 95% CI 0.44–0.99). CONCLUSIONS: In Eñepa children high S. pneumoniae carriage rates associated with a poor nutritional status contribute to the development of ARTIs.
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spelling pubmed-71733372020-04-22 Respiratory infections in Eñepa Amerindians are related to malnutrition and Streptococcus pneumoniae carriage Verhagen, Lilly M. Gómez-Castellano, Keyla Snelders, Eveline Rivera-Olivero, Ismar Pocaterra, Leonor Melchers, Willem J.G. de Waard, Jacobus H. Hermans, Peter W.M. J Infect Article OBJECTIVES: High acute respiratory tract infection (ARTI) rates are observed in indigenous populations. We assessed the role of viral infections and nasopharyngeal bacterial carriage in ARTIs in Eñepa Amerindians from Venezuela. METHODS: In 40 children aged 0–10 years with ARTIs, healthy nearest-age sibling controls and their mothers the presence of Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Moraxella catarrhalis, Mycoplasma pneumoniae, Chlamydophila pneumoniae/psittachi and 15 respiratory viruses was investigated. RESULTS: S. pneumoniae was the most frequently detected pathogen, with carriage rates of 75% and 38% in children and mothers respectively. In children, S. pneumoniae carriage was associated with ARTI risk in multivariate analysis (OR 14.1, 95% CI 1.4–137.7). Viral infections were not associated with ARTI risk. S. pneumoniae carriage was common in children of all ages while viral co-infections were more frequently present in children under 4 years compared to older children (46% vs. 17%, p < 0.01). An increase of one unit height-for-age Z score (i.e. improved chronic nutritional status) was associated with decreased odds of S. pneumoniae colonization in multivariate analysis (OR 0.66, 95% CI 0.44–0.99). CONCLUSIONS: In Eñepa children high S. pneumoniae carriage rates associated with a poor nutritional status contribute to the development of ARTIs. The British Infection Association. Published by Elsevier Ltd. 2013-10 2013-06-22 /pmc/articles/PMC7173337/ /pubmed/23796866 http://dx.doi.org/10.1016/j.jinf.2013.06.010 Text en Copyright © 2013 The British Infection Association. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Verhagen, Lilly M.
Gómez-Castellano, Keyla
Snelders, Eveline
Rivera-Olivero, Ismar
Pocaterra, Leonor
Melchers, Willem J.G.
de Waard, Jacobus H.
Hermans, Peter W.M.
Respiratory infections in Eñepa Amerindians are related to malnutrition and Streptococcus pneumoniae carriage
title Respiratory infections in Eñepa Amerindians are related to malnutrition and Streptococcus pneumoniae carriage
title_full Respiratory infections in Eñepa Amerindians are related to malnutrition and Streptococcus pneumoniae carriage
title_fullStr Respiratory infections in Eñepa Amerindians are related to malnutrition and Streptococcus pneumoniae carriage
title_full_unstemmed Respiratory infections in Eñepa Amerindians are related to malnutrition and Streptococcus pneumoniae carriage
title_short Respiratory infections in Eñepa Amerindians are related to malnutrition and Streptococcus pneumoniae carriage
title_sort respiratory infections in eñepa amerindians are related to malnutrition and streptococcus pneumoniae carriage
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173337/
https://www.ncbi.nlm.nih.gov/pubmed/23796866
http://dx.doi.org/10.1016/j.jinf.2013.06.010
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