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The Role of Stem Cell Factor in Hyperpigmented Skin Lesions
BACKGROUND: Skin hyperpigmentation usually results from an increased number, or activity, of melanocytes. The degree of pigmentation of skin depends on the amount and type of melanin, degree of skin vascularity, presence of carotene, and thickness of the stratum corneum. Common causes of hyperpigmen...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
West Asia Organization for Cancer Prevention
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173358/ https://www.ncbi.nlm.nih.gov/pubmed/31870114 http://dx.doi.org/10.31557/APJCP.2019.20.12.3723 |
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author | Atef, Aliaa El-Rashidy, Mohamed A Azeem, Amal Abdel Kabel, Ahmed M |
author_facet | Atef, Aliaa El-Rashidy, Mohamed A Azeem, Amal Abdel Kabel, Ahmed M |
author_sort | Atef, Aliaa |
collection | PubMed |
description | BACKGROUND: Skin hyperpigmentation usually results from an increased number, or activity, of melanocytes. The degree of pigmentation of skin depends on the amount and type of melanin, degree of skin vascularity, presence of carotene, and thickness of the stratum corneum. Common causes of hyperpigmentation include post-inflammatory hyperpigmentation, melasma, solar lentigines, ephelides (freckles), and café-au-lait macules. Some skin tumors can be hyperpigmented as basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and malignant melanoma (MM). Stem cell factor (SCF) is a growth factor and its interaction with its receptor, c-kit, is well known to be critical to the survival of melanocytes. METHODS: This study was carried out on 60 patients complaining of hyperpigmented skin lesions (20 melasma, 20 solar lentigines, and 20 freckles) and 36 patients with skin tumors (14 BCC, 12 SCC, and 10 MM). Punch skin biopsies were taken from the previous lesions. Immunohistochemical staining of these samples was done using the stem cell factor (SCF). RESULTS: There was positive expression of SCF in all cases of melasma, solar lentigines and freckles with significant increase in the intensity of expression in the lesional areas than the non-lesional ones (P=0.004). There was also a statistically significant increase in the expression of SCF in BCC and melanoma tumor cells. CONCLUSION: SCF has a great role in skin hyperpigmented disorders and this can be used as a target for the developing of new antipigmentary lines of treatment by inhibiting SCF. SCF can also be involved in the emergence of some skin tumors. |
format | Online Article Text |
id | pubmed-7173358 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | West Asia Organization for Cancer Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-71733582020-05-01 The Role of Stem Cell Factor in Hyperpigmented Skin Lesions Atef, Aliaa El-Rashidy, Mohamed A Azeem, Amal Abdel Kabel, Ahmed M Asian Pac J Cancer Prev Research Article BACKGROUND: Skin hyperpigmentation usually results from an increased number, or activity, of melanocytes. The degree of pigmentation of skin depends on the amount and type of melanin, degree of skin vascularity, presence of carotene, and thickness of the stratum corneum. Common causes of hyperpigmentation include post-inflammatory hyperpigmentation, melasma, solar lentigines, ephelides (freckles), and café-au-lait macules. Some skin tumors can be hyperpigmented as basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and malignant melanoma (MM). Stem cell factor (SCF) is a growth factor and its interaction with its receptor, c-kit, is well known to be critical to the survival of melanocytes. METHODS: This study was carried out on 60 patients complaining of hyperpigmented skin lesions (20 melasma, 20 solar lentigines, and 20 freckles) and 36 patients with skin tumors (14 BCC, 12 SCC, and 10 MM). Punch skin biopsies were taken from the previous lesions. Immunohistochemical staining of these samples was done using the stem cell factor (SCF). RESULTS: There was positive expression of SCF in all cases of melasma, solar lentigines and freckles with significant increase in the intensity of expression in the lesional areas than the non-lesional ones (P=0.004). There was also a statistically significant increase in the expression of SCF in BCC and melanoma tumor cells. CONCLUSION: SCF has a great role in skin hyperpigmented disorders and this can be used as a target for the developing of new antipigmentary lines of treatment by inhibiting SCF. SCF can also be involved in the emergence of some skin tumors. West Asia Organization for Cancer Prevention 2019 /pmc/articles/PMC7173358/ /pubmed/31870114 http://dx.doi.org/10.31557/APJCP.2019.20.12.3723 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Atef, Aliaa El-Rashidy, Mohamed A Azeem, Amal Abdel Kabel, Ahmed M The Role of Stem Cell Factor in Hyperpigmented Skin Lesions |
title | The Role of Stem Cell Factor in Hyperpigmented Skin Lesions |
title_full | The Role of Stem Cell Factor in Hyperpigmented Skin Lesions |
title_fullStr | The Role of Stem Cell Factor in Hyperpigmented Skin Lesions |
title_full_unstemmed | The Role of Stem Cell Factor in Hyperpigmented Skin Lesions |
title_short | The Role of Stem Cell Factor in Hyperpigmented Skin Lesions |
title_sort | role of stem cell factor in hyperpigmented skin lesions |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173358/ https://www.ncbi.nlm.nih.gov/pubmed/31870114 http://dx.doi.org/10.31557/APJCP.2019.20.12.3723 |
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