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Role of Inflammatory Markers in Prognosis of Oral Squamous Cell Carcinoma

BACKGROUND: This estudie evaluated the immunostaining of cytokines in oral carcinoma, in tissue of margin of surgical resecate (MSR) and metastatic lymph nodes, as well as their role in patient prognosis. METHODS: A retrospective study was carried out in patients with oral squamous cell carcinomas,...

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Autores principales: Dantas, Thinali Sousa, Silva, Paulo Goberlânio de Barros, Verde, Maria Elisa Quezado Lima, Júnior, Aloísio de Lima Ribeiro, Cunha, Maria do Perpétuo Socorro Saldanha, Mota, Mário Rogério Lima, Alves, Ana Paula Negreiros Nunes, Leitão, Renata Ferreira de Carvalho, Sousa, Fabrício Bitu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173367/
https://www.ncbi.nlm.nih.gov/pubmed/31870104
http://dx.doi.org/10.31557/APJCP.2019.20.12.3635
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author Dantas, Thinali Sousa
Silva, Paulo Goberlânio de Barros
Verde, Maria Elisa Quezado Lima
Júnior, Aloísio de Lima Ribeiro
Cunha, Maria do Perpétuo Socorro Saldanha
Mota, Mário Rogério Lima
Alves, Ana Paula Negreiros Nunes
Leitão, Renata Ferreira de Carvalho
Sousa, Fabrício Bitu
author_facet Dantas, Thinali Sousa
Silva, Paulo Goberlânio de Barros
Verde, Maria Elisa Quezado Lima
Júnior, Aloísio de Lima Ribeiro
Cunha, Maria do Perpétuo Socorro Saldanha
Mota, Mário Rogério Lima
Alves, Ana Paula Negreiros Nunes
Leitão, Renata Ferreira de Carvalho
Sousa, Fabrício Bitu
author_sort Dantas, Thinali Sousa
collection PubMed
description BACKGROUND: This estudie evaluated the immunostaining of cytokines in oral carcinoma, in tissue of margin of surgical resecate (MSR) and metastatic lymph nodes, as well as their role in patient prognosis. METHODS: A retrospective study was carried out in patients with oral squamous cell carcinomas, and sociodemographic and clinical-pathological data were evaluated. In addition, surgical site analysis of the patients was conducted by immunohistochemistry, using a tissue microarray for inflammatory (Tumor Necrosis Factor-alpha, Interleukin-1beta, Interleukin-6, interleukin-10), transcription NF-kappa B and CD68 markers. Immunoexpression was assessed qualitatively and quantitatively using ImageJ software, and data were correlated with the prognostic factors and patient survival rates. RESULTS: There was a greater immunoexpression of inflammatory and CD68 cytokines in primary tumour and lymph node metastasis than in MSR. In a multinomial logistic regression model, patients with low education (p = 0.041) and a high histoscore for TNF-α (p = 0.021) showed a survival rate of 15.64 (95% CI = 1.13-217.24) and 6.81 (95% CI = 1.02-105.96). CONCLUSION: Therefore, despite there is an increased immunoexpression of cytokines in the primary tumour, only TNF-α was the inflammatory cytokine that influenced the survival of patients with oral cancer.
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spelling pubmed-71733672020-05-01 Role of Inflammatory Markers in Prognosis of Oral Squamous Cell Carcinoma Dantas, Thinali Sousa Silva, Paulo Goberlânio de Barros Verde, Maria Elisa Quezado Lima Júnior, Aloísio de Lima Ribeiro Cunha, Maria do Perpétuo Socorro Saldanha Mota, Mário Rogério Lima Alves, Ana Paula Negreiros Nunes Leitão, Renata Ferreira de Carvalho Sousa, Fabrício Bitu Asian Pac J Cancer Prev Research Article BACKGROUND: This estudie evaluated the immunostaining of cytokines in oral carcinoma, in tissue of margin of surgical resecate (MSR) and metastatic lymph nodes, as well as their role in patient prognosis. METHODS: A retrospective study was carried out in patients with oral squamous cell carcinomas, and sociodemographic and clinical-pathological data were evaluated. In addition, surgical site analysis of the patients was conducted by immunohistochemistry, using a tissue microarray for inflammatory (Tumor Necrosis Factor-alpha, Interleukin-1beta, Interleukin-6, interleukin-10), transcription NF-kappa B and CD68 markers. Immunoexpression was assessed qualitatively and quantitatively using ImageJ software, and data were correlated with the prognostic factors and patient survival rates. RESULTS: There was a greater immunoexpression of inflammatory and CD68 cytokines in primary tumour and lymph node metastasis than in MSR. In a multinomial logistic regression model, patients with low education (p = 0.041) and a high histoscore for TNF-α (p = 0.021) showed a survival rate of 15.64 (95% CI = 1.13-217.24) and 6.81 (95% CI = 1.02-105.96). CONCLUSION: Therefore, despite there is an increased immunoexpression of cytokines in the primary tumour, only TNF-α was the inflammatory cytokine that influenced the survival of patients with oral cancer. West Asia Organization for Cancer Prevention 2019 /pmc/articles/PMC7173367/ /pubmed/31870104 http://dx.doi.org/10.31557/APJCP.2019.20.12.3635 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Dantas, Thinali Sousa
Silva, Paulo Goberlânio de Barros
Verde, Maria Elisa Quezado Lima
Júnior, Aloísio de Lima Ribeiro
Cunha, Maria do Perpétuo Socorro Saldanha
Mota, Mário Rogério Lima
Alves, Ana Paula Negreiros Nunes
Leitão, Renata Ferreira de Carvalho
Sousa, Fabrício Bitu
Role of Inflammatory Markers in Prognosis of Oral Squamous Cell Carcinoma
title Role of Inflammatory Markers in Prognosis of Oral Squamous Cell Carcinoma
title_full Role of Inflammatory Markers in Prognosis of Oral Squamous Cell Carcinoma
title_fullStr Role of Inflammatory Markers in Prognosis of Oral Squamous Cell Carcinoma
title_full_unstemmed Role of Inflammatory Markers in Prognosis of Oral Squamous Cell Carcinoma
title_short Role of Inflammatory Markers in Prognosis of Oral Squamous Cell Carcinoma
title_sort role of inflammatory markers in prognosis of oral squamous cell carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173367/
https://www.ncbi.nlm.nih.gov/pubmed/31870104
http://dx.doi.org/10.31557/APJCP.2019.20.12.3635
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