Cargando…
Role of Inflammatory Markers in Prognosis of Oral Squamous Cell Carcinoma
BACKGROUND: This estudie evaluated the immunostaining of cytokines in oral carcinoma, in tissue of margin of surgical resecate (MSR) and metastatic lymph nodes, as well as their role in patient prognosis. METHODS: A retrospective study was carried out in patients with oral squamous cell carcinomas,...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
West Asia Organization for Cancer Prevention
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173367/ https://www.ncbi.nlm.nih.gov/pubmed/31870104 http://dx.doi.org/10.31557/APJCP.2019.20.12.3635 |
_version_ | 1783524436374192128 |
---|---|
author | Dantas, Thinali Sousa Silva, Paulo Goberlânio de Barros Verde, Maria Elisa Quezado Lima Júnior, Aloísio de Lima Ribeiro Cunha, Maria do Perpétuo Socorro Saldanha Mota, Mário Rogério Lima Alves, Ana Paula Negreiros Nunes Leitão, Renata Ferreira de Carvalho Sousa, Fabrício Bitu |
author_facet | Dantas, Thinali Sousa Silva, Paulo Goberlânio de Barros Verde, Maria Elisa Quezado Lima Júnior, Aloísio de Lima Ribeiro Cunha, Maria do Perpétuo Socorro Saldanha Mota, Mário Rogério Lima Alves, Ana Paula Negreiros Nunes Leitão, Renata Ferreira de Carvalho Sousa, Fabrício Bitu |
author_sort | Dantas, Thinali Sousa |
collection | PubMed |
description | BACKGROUND: This estudie evaluated the immunostaining of cytokines in oral carcinoma, in tissue of margin of surgical resecate (MSR) and metastatic lymph nodes, as well as their role in patient prognosis. METHODS: A retrospective study was carried out in patients with oral squamous cell carcinomas, and sociodemographic and clinical-pathological data were evaluated. In addition, surgical site analysis of the patients was conducted by immunohistochemistry, using a tissue microarray for inflammatory (Tumor Necrosis Factor-alpha, Interleukin-1beta, Interleukin-6, interleukin-10), transcription NF-kappa B and CD68 markers. Immunoexpression was assessed qualitatively and quantitatively using ImageJ software, and data were correlated with the prognostic factors and patient survival rates. RESULTS: There was a greater immunoexpression of inflammatory and CD68 cytokines in primary tumour and lymph node metastasis than in MSR. In a multinomial logistic regression model, patients with low education (p = 0.041) and a high histoscore for TNF-α (p = 0.021) showed a survival rate of 15.64 (95% CI = 1.13-217.24) and 6.81 (95% CI = 1.02-105.96). CONCLUSION: Therefore, despite there is an increased immunoexpression of cytokines in the primary tumour, only TNF-α was the inflammatory cytokine that influenced the survival of patients with oral cancer. |
format | Online Article Text |
id | pubmed-7173367 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | West Asia Organization for Cancer Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-71733672020-05-01 Role of Inflammatory Markers in Prognosis of Oral Squamous Cell Carcinoma Dantas, Thinali Sousa Silva, Paulo Goberlânio de Barros Verde, Maria Elisa Quezado Lima Júnior, Aloísio de Lima Ribeiro Cunha, Maria do Perpétuo Socorro Saldanha Mota, Mário Rogério Lima Alves, Ana Paula Negreiros Nunes Leitão, Renata Ferreira de Carvalho Sousa, Fabrício Bitu Asian Pac J Cancer Prev Research Article BACKGROUND: This estudie evaluated the immunostaining of cytokines in oral carcinoma, in tissue of margin of surgical resecate (MSR) and metastatic lymph nodes, as well as their role in patient prognosis. METHODS: A retrospective study was carried out in patients with oral squamous cell carcinomas, and sociodemographic and clinical-pathological data were evaluated. In addition, surgical site analysis of the patients was conducted by immunohistochemistry, using a tissue microarray for inflammatory (Tumor Necrosis Factor-alpha, Interleukin-1beta, Interleukin-6, interleukin-10), transcription NF-kappa B and CD68 markers. Immunoexpression was assessed qualitatively and quantitatively using ImageJ software, and data were correlated with the prognostic factors and patient survival rates. RESULTS: There was a greater immunoexpression of inflammatory and CD68 cytokines in primary tumour and lymph node metastasis than in MSR. In a multinomial logistic regression model, patients with low education (p = 0.041) and a high histoscore for TNF-α (p = 0.021) showed a survival rate of 15.64 (95% CI = 1.13-217.24) and 6.81 (95% CI = 1.02-105.96). CONCLUSION: Therefore, despite there is an increased immunoexpression of cytokines in the primary tumour, only TNF-α was the inflammatory cytokine that influenced the survival of patients with oral cancer. West Asia Organization for Cancer Prevention 2019 /pmc/articles/PMC7173367/ /pubmed/31870104 http://dx.doi.org/10.31557/APJCP.2019.20.12.3635 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Dantas, Thinali Sousa Silva, Paulo Goberlânio de Barros Verde, Maria Elisa Quezado Lima Júnior, Aloísio de Lima Ribeiro Cunha, Maria do Perpétuo Socorro Saldanha Mota, Mário Rogério Lima Alves, Ana Paula Negreiros Nunes Leitão, Renata Ferreira de Carvalho Sousa, Fabrício Bitu Role of Inflammatory Markers in Prognosis of Oral Squamous Cell Carcinoma |
title | Role of Inflammatory Markers in Prognosis of Oral Squamous Cell Carcinoma |
title_full | Role of Inflammatory Markers in Prognosis of Oral Squamous Cell Carcinoma |
title_fullStr | Role of Inflammatory Markers in Prognosis of Oral Squamous Cell Carcinoma |
title_full_unstemmed | Role of Inflammatory Markers in Prognosis of Oral Squamous Cell Carcinoma |
title_short | Role of Inflammatory Markers in Prognosis of Oral Squamous Cell Carcinoma |
title_sort | role of inflammatory markers in prognosis of oral squamous cell carcinoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173367/ https://www.ncbi.nlm.nih.gov/pubmed/31870104 http://dx.doi.org/10.31557/APJCP.2019.20.12.3635 |
work_keys_str_mv | AT dantasthinalisousa roleofinflammatorymarkersinprognosisoforalsquamouscellcarcinoma AT silvapaulogoberlaniodebarros roleofinflammatorymarkersinprognosisoforalsquamouscellcarcinoma AT verdemariaelisaquezadolima roleofinflammatorymarkersinprognosisoforalsquamouscellcarcinoma AT junioraloisiodelimaribeiro roleofinflammatorymarkersinprognosisoforalsquamouscellcarcinoma AT cunhamariadoperpetuosocorrosaldanha roleofinflammatorymarkersinprognosisoforalsquamouscellcarcinoma AT motamariorogeriolima roleofinflammatorymarkersinprognosisoforalsquamouscellcarcinoma AT alvesanapaulanegreirosnunes roleofinflammatorymarkersinprognosisoforalsquamouscellcarcinoma AT leitaorenataferreiradecarvalho roleofinflammatorymarkersinprognosisoforalsquamouscellcarcinoma AT sousafabriciobitu roleofinflammatorymarkersinprognosisoforalsquamouscellcarcinoma |