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Antibacterial and Anticancer Activities of Fenugreek Seed Extract
This work is about the utilization of fenugreek seed as an antibacterial and anticancer agents. The antibacterial activity of fenugreek seed extract on six pathological bacteria strains were specified through conventional biochemical tests using the Vitek2 automated system and diffusion agar method....
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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West Asia Organization for Cancer Prevention
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173369/ https://www.ncbi.nlm.nih.gov/pubmed/31870120 http://dx.doi.org/10.31557/APJCP.2019.20.12.3771 |
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author | Al-Timimi, Lina A Naser |
author_facet | Al-Timimi, Lina A Naser |
author_sort | Al-Timimi, Lina A Naser |
collection | PubMed |
description | This work is about the utilization of fenugreek seed as an antibacterial and anticancer agents. The antibacterial activity of fenugreek seed extract on six pathological bacteria strains were specified through conventional biochemical tests using the Vitek2 automated system and diffusion agar method. The anticancer activities of fenugreek seed extract, on MCF-7 breast cancer cells, liver cancer HCAM cells and the non-cancerous Vero cell lines, were investigated using colorimetric MTT assay. Results showed that the highest activity of the extract of the seed was found on Staphylococcus aureus and Pseudomonas aeruginosa (22 mm and 17 mm diameter of inhibition zones respectively). The seed extract showed proliferative inhibition on MCF-7 cell line at a concentration of 400 µg/ml and 72 h of the incubation period. This was accompanied by insignificant apoptosis or necrosis. The seed extract showed no anticancer effect on liver and Vero cell lines. This work emphasizes that fenugreek seed extract is a potential source of antibacterial and anticancer agents. |
format | Online Article Text |
id | pubmed-7173369 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | West Asia Organization for Cancer Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-71733692020-05-01 Antibacterial and Anticancer Activities of Fenugreek Seed Extract Al-Timimi, Lina A Naser Asian Pac J Cancer Prev Research Article This work is about the utilization of fenugreek seed as an antibacterial and anticancer agents. The antibacterial activity of fenugreek seed extract on six pathological bacteria strains were specified through conventional biochemical tests using the Vitek2 automated system and diffusion agar method. The anticancer activities of fenugreek seed extract, on MCF-7 breast cancer cells, liver cancer HCAM cells and the non-cancerous Vero cell lines, were investigated using colorimetric MTT assay. Results showed that the highest activity of the extract of the seed was found on Staphylococcus aureus and Pseudomonas aeruginosa (22 mm and 17 mm diameter of inhibition zones respectively). The seed extract showed proliferative inhibition on MCF-7 cell line at a concentration of 400 µg/ml and 72 h of the incubation period. This was accompanied by insignificant apoptosis or necrosis. The seed extract showed no anticancer effect on liver and Vero cell lines. This work emphasizes that fenugreek seed extract is a potential source of antibacterial and anticancer agents. West Asia Organization for Cancer Prevention 2019 /pmc/articles/PMC7173369/ /pubmed/31870120 http://dx.doi.org/10.31557/APJCP.2019.20.12.3771 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Al-Timimi, Lina A Naser Antibacterial and Anticancer Activities of Fenugreek Seed Extract |
title | Antibacterial and Anticancer Activities of Fenugreek Seed Extract |
title_full | Antibacterial and Anticancer Activities of Fenugreek Seed Extract |
title_fullStr | Antibacterial and Anticancer Activities of Fenugreek Seed Extract |
title_full_unstemmed | Antibacterial and Anticancer Activities of Fenugreek Seed Extract |
title_short | Antibacterial and Anticancer Activities of Fenugreek Seed Extract |
title_sort | antibacterial and anticancer activities of fenugreek seed extract |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173369/ https://www.ncbi.nlm.nih.gov/pubmed/31870120 http://dx.doi.org/10.31557/APJCP.2019.20.12.3771 |
work_keys_str_mv | AT altimimilinaanaser antibacterialandanticanceractivitiesoffenugreekseedextract |