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Trends in the Incidence of Breast Cancer Following the Radiological Accident in Goiânia: A 25-Year Analysis

BACKGROUND: The largest radiological accident to occur in any urban area happened in Goiânia, Brazil, in 1987. One major concern regarding deleterious effects in the population was a possible increase in the breast cancer incidence. This study analyzed trends in the incidence of breast cancer over t...

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Autores principales: Rahal, Rosemar Macedo Sousa, Rocha, Marina Elias, Freitas-Junior, Ruffo, Corrêa, Rosangela da Silveira, Rodrigues, Danielle, Martins, Edesio, Soares, Leonardo Ribeiro, Oliveira, Jose Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173397/
https://www.ncbi.nlm.nih.gov/pubmed/31870126
http://dx.doi.org/10.31557/APJCP.2019.20.12.3811
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author Rahal, Rosemar Macedo Sousa
Rocha, Marina Elias
Freitas-Junior, Ruffo
Corrêa, Rosangela da Silveira
Rodrigues, Danielle
Martins, Edesio
Soares, Leonardo Ribeiro
Oliveira, Jose Carlos
author_facet Rahal, Rosemar Macedo Sousa
Rocha, Marina Elias
Freitas-Junior, Ruffo
Corrêa, Rosangela da Silveira
Rodrigues, Danielle
Martins, Edesio
Soares, Leonardo Ribeiro
Oliveira, Jose Carlos
author_sort Rahal, Rosemar Macedo Sousa
collection PubMed
description BACKGROUND: The largest radiological accident to occur in any urban area happened in Goiânia, Brazil, in 1987. One major concern regarding deleterious effects in the population was a possible increase in the breast cancer incidence. This study analyzed trends in the incidence of breast cancer over the 25-year period following the radiological accident. METHODS: This ecological, population-based study was conducted to determine the incidence of breast cancer in female residents of Goiânia, Goiás, Brazil, between 1988 and 2012. The data were collected from the Goiânia population-based cancer registry. Crude and age-standardized incidence rates were calculated. The Joinpoint software program was used to calculate annual percent changes (APC) in the incidence of breast cancer. RESULTS: Overall, 7,365 new cases of breast cancer were identified, with an annual crude incidence rate of 23.09/100,000 women in 1988 and of 71.65/100,000 women in 2012. The age-standardized incidence rate was 35.63/100,000 women in 1988 and 65.63/100,000 women in 2012. Analysis of the APC showed a significant annual increase of 4.8% in the incidence between 1988 and 2005 (p<0.0001) followed by stabilization in 2005-2012, with an APC of -3.5% (p=0.1). CONCLUSION: There was an increase in the incidence of breast cancer in the female residents of Goiânia, Goiás in the first 17 years of evaluation (1988-2004) followed by a period of stabilization until 2012. However, the trends in the incidence suggest a lack of association with the radiological accident.
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spelling pubmed-71733972020-05-01 Trends in the Incidence of Breast Cancer Following the Radiological Accident in Goiânia: A 25-Year Analysis Rahal, Rosemar Macedo Sousa Rocha, Marina Elias Freitas-Junior, Ruffo Corrêa, Rosangela da Silveira Rodrigues, Danielle Martins, Edesio Soares, Leonardo Ribeiro Oliveira, Jose Carlos Asian Pac J Cancer Prev Research Article BACKGROUND: The largest radiological accident to occur in any urban area happened in Goiânia, Brazil, in 1987. One major concern regarding deleterious effects in the population was a possible increase in the breast cancer incidence. This study analyzed trends in the incidence of breast cancer over the 25-year period following the radiological accident. METHODS: This ecological, population-based study was conducted to determine the incidence of breast cancer in female residents of Goiânia, Goiás, Brazil, between 1988 and 2012. The data were collected from the Goiânia population-based cancer registry. Crude and age-standardized incidence rates were calculated. The Joinpoint software program was used to calculate annual percent changes (APC) in the incidence of breast cancer. RESULTS: Overall, 7,365 new cases of breast cancer were identified, with an annual crude incidence rate of 23.09/100,000 women in 1988 and of 71.65/100,000 women in 2012. The age-standardized incidence rate was 35.63/100,000 women in 1988 and 65.63/100,000 women in 2012. Analysis of the APC showed a significant annual increase of 4.8% in the incidence between 1988 and 2005 (p<0.0001) followed by stabilization in 2005-2012, with an APC of -3.5% (p=0.1). CONCLUSION: There was an increase in the incidence of breast cancer in the female residents of Goiânia, Goiás in the first 17 years of evaluation (1988-2004) followed by a period of stabilization until 2012. However, the trends in the incidence suggest a lack of association with the radiological accident. West Asia Organization for Cancer Prevention 2019 /pmc/articles/PMC7173397/ /pubmed/31870126 http://dx.doi.org/10.31557/APJCP.2019.20.12.3811 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Rahal, Rosemar Macedo Sousa
Rocha, Marina Elias
Freitas-Junior, Ruffo
Corrêa, Rosangela da Silveira
Rodrigues, Danielle
Martins, Edesio
Soares, Leonardo Ribeiro
Oliveira, Jose Carlos
Trends in the Incidence of Breast Cancer Following the Radiological Accident in Goiânia: A 25-Year Analysis
title Trends in the Incidence of Breast Cancer Following the Radiological Accident in Goiânia: A 25-Year Analysis
title_full Trends in the Incidence of Breast Cancer Following the Radiological Accident in Goiânia: A 25-Year Analysis
title_fullStr Trends in the Incidence of Breast Cancer Following the Radiological Accident in Goiânia: A 25-Year Analysis
title_full_unstemmed Trends in the Incidence of Breast Cancer Following the Radiological Accident in Goiânia: A 25-Year Analysis
title_short Trends in the Incidence of Breast Cancer Following the Radiological Accident in Goiânia: A 25-Year Analysis
title_sort trends in the incidence of breast cancer following the radiological accident in goiânia: a 25-year analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173397/
https://www.ncbi.nlm.nih.gov/pubmed/31870126
http://dx.doi.org/10.31557/APJCP.2019.20.12.3811
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